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2024-04-23 12:29 |
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2024-04-15 11:55 |
[FZJ-2024-02776]
Abstract
Kocher, M. ; Heinzel, A. ; Mottaghy, F. M. ; et al
P01.01.A THE IMPACT OF BRAIN LESIONS ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH WHO CNS GRADE 3 OR 4 GLIOMA: A LESION-FUNCTION AND RESTING-STATE FMRI ANALYSIS
2023 18th Meeting of the European Association of Neuro-Oncology , RotterdamRotterdam, Netherlands, 21 Sep 2023 - 24 Sep 20232023-09-212023-09-24
(2023) [10.1093/neuonc/noad137.075]2023
BACKGROUNDIn glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL.MATERIAL AND METHODSIn 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. [...]
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2024-04-15 11:45 |
[FZJ-2024-02773]
Abstract
Friedrich, M. ; Stoffels, G. ; Filss, C. P. ; et al
P01.02.A WHOLE-BRAIN STRUCTURAL CONNECTIVITY PREDICTS COGNITIVE OUTCOMES IN PRETREATED PATIENTS WITH WHO GRADE 3 OR 4 GLIOMAS
202318th Meeting of the European Association of Neuro-Oncology , RotterdamRotterdam, Netherlands, 21 Sep 2023 - 24 Sep 20232023-09-212023-09-24
(2023) [10.1093/neuonc/noad137.076]2023
BACKGROUNDGlioma patients frequently suffer from cognitive dysfunction potentially related to brain damage caused by tumor invasion or therapeutic intervention. We hypothesized that, as in other neurological disorders, the long-term outcome of cognitive functions in glioma patients critically depends on maintaining the structural connectivity of multiple interconnected networks.PATIENTS AND METHODSOne hundred and twenty-one glioma patients (median age, 52 years; median ECOG score, 1) with histomolecularly characterized CNS WHO grade 3 or 4 gliomas were investigated after a median time of 14 months (range, 1-214 months) following first-line therapy, including resection and chemoradiation with alkylating agents. [...]
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