Open Access

The turbulent fluxes of momentum, heat and water vapour link the Earth's surface with the atmosphere. The correct modelling of the flux interactions between these two systems with very different time scales is therefore vital for climate (resp. [...]

Background:In the last years, different biotechnologically relevant microorganisms have been engineered for the synthesis of plant polyphenols such as flavonoids and stilbenes. However, low intracellular availability of malonyl-CoA as essential precursor for most plant polyphenols of interest is regarded as the decisive bottleneck preventing high product titers.Results:In this study, Corynebacterium glutamicum, which emerged as promising cell factory for plant polyphenol production, was tailored by rational metabolic engineering towards providing significantly more malonyl-CoA for product synthesis. [...]

Artificial neural networks (ANNs) are common to solve non-linear relationships between input and output variablesas universal approximators. Functional relations can often be expressed by shallow and quite simple feedforward networks, also known as multilayer perceptrons (MLPs). [...]

The fundamental aim of structural analyses in biophysics is to reveal a mutual relation between a molecule’s dynamic structure and its physiological function. Small-angle X-ray scattering (SAXS) is an experimental technique for structural characterization of macromolecules in solution and enables time-resolved analysis of conformational changes under physiological conditions. [...]

The existing development trend towards „more electric aircraft” architectures means a steadygrowth in electrical power demand on board of aircrafts. For various reasons fuel cells may beideally suited for covering the electrical power demand of future commercial aircraft [...]