Temporäre Einträge

Purpose: Treatment of patients undergoing prolonged weaning from mechanical ventilation includes repeatedspontaneous breathing trials (SBTs) without respiratory support, whose duration must be balanced critically toprevent over- and underload of respiratory musculature. This study aimed to develop a machine learning modelto predict the duration of unassisted spontaneous breathing.Materials and methods: Structured clinical data of patients from a specialized weaning unit were used to develop(1) a classifier model to qualitatively predict an increase of duration, (2) a regressor model to quantitativelypredict the precise duration of SBTs on the next day, and (3) the duration difference between the current andfollowing day. [...]

The pathological misfolding and aggregation of soluble α-synuclein into toxic oligomers and insoluble amyloid fibrils causes Parkinson’s disease, a progressive age-related neurodegenerative disease for which there is no cure. HET-s is a soluble fungal protein that can form assembled amyloid fibrils in its prion state. [...]

Recent years have witnessed the advent of increasingly large datasets of the human brain, both in terms of aggregated participants and/or the number of measurements taken per participant. These resources provide unparalleled chances to investigate the organization of human brain at both individual and population levels, spanning various spatial and temporal scales. [...]