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2016-09-29
12:19
[FZJ-2016-05061] Journal Article
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Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
Stress increases the risk for major depressive disorder (MDD), overeating, and alcohol dependence (AD). The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the neuropeptide Y receptor Y2 (NPY2R). [...]

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2016-09-29
12:16
[FZJ-2016-05060] Journal Article
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Implementation errors in the GingerALE Software: Description and recommendations.
Neuroscience imaging is a burgeoning, highly sophisticated field the growth of which has been fostered by grant-funded, freely distributed software libraries that perform voxel-wise analyses in anatomically standardized three-dimensional space on multi-subject, whole-brain, primary datasets. Despite the ongoing advances made using these non-commercial computational tools, the replicability of individual studies is an acknowledged limitation. [...]

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2016-09-29
12:13
[FZJ-2016-05059] Journal Article
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Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma
Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of therapeutic intervention on the clonal composition of solid tumors.Here, we used 33 single cell-derived subclones generated from five clinical glioblastoma specimens for exploring intra- and inter-individual spectra of drug resistance profiles in vitro. [...]

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2016-09-29
12:07
[FZJ-2016-05058] Journal Article
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Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress.
Resveratrol has gained tremendous interest owing to multiple reported health-beneficial effects. However, the underlying key mechanism of action of resveratrol remained largely controversial. [...]

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2016-09-29
12:05
[FZJ-2016-05057] Journal Article
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Resting-state test-retest reliability of a priori defined canonical networks over different preprocessing steps.
Resting-state functional connectivity analysis has become a widely used method for the investigation of human brain connectivity and pathology. The measurement of neuronal activity by functional MRI, however, is impeded by various nuisance signals that reduce the stability of functional connectivity. [...]

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2016-09-29
12:02
[FZJ-2016-05055] Journal Article
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Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
Genome-wide analysis (GWA) is an effective strategy to discover extreme effects surpassing genome-wide significant levels in studying complex disorders; however, when sample size is limited, the true effects may fail to achieve genome-wide significance. In such case, there may be authentic results among the pools of nominal candidates, and an alternative approach is to consider nominal candidates but are replicable across different samples. [...]

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2016-09-29
11:58
[FZJ-2016-05054] Journal Article
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Functional Decoding and Meta-Analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder.
Task-based functional magnetic resonance imaging (fMRI) studies of adult attention-deficit/hyperactivity disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies.We first conducted an activation likelihood estimation meta-analysis of 24 task-based fMRI studies in adults with ADHD. [...]

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2016-09-29
11:56
[FZJ-2016-05053] Journal Article
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Consensus paper of the WFSBP Task Force on Genetics: Genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response.1
Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-economic burden. Antidepressants of different classes are prescribed to treat MDD, but reliable and reproducible markers of efficacy are not available for clinical use. [...]

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2016-09-29
11:12
[FZJ-2016-05049] Journal Article
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Corrosion of non-irradiated UAlx–Al fuel in the presence of clay pore solution: a quantitative XRD secondary phase analysis applying the DDM method
Corrosion experiments with non-irradiated metallic UAlx–Al research reactor fuel elements were carried out in autoclaves to identify and quantify the corrosion products. Such compounds, considering the long-term safety assessment of final repositories, can interact with the released inventory and this constitutes a sink for radionuclide migration in formation waters. [...]

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2016-09-28
08:39
[FZJ-2016-05024] Master Thesis

Verfolgung von Bluetooth-LE Beacons bei fest installierten Empfängern
IX, 79 p. (2016)
Im Rahmen dieser Ausarbeitung wird das bisherige Standardszenario der Innenraumlokalisierung mittels Bluetooth Low Energy umgedreht. Das bedeutet, dass anhand von stationären Empfängern untersucht wird, wie gut sich sendende Bluetooth-LE-Beacons durch ein Fingerprinting-Verfahren lokalisieren lassen.Dazu wird zunächst auf Grundlagen der Bluetooth-Technologie eingegangen, um mögliche Fehlerquellen zwischen Sendern und Empfängern zu identifizieren. [...]
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