2024-04-15 11:55 |
[FZJ-2024-02776]
Abstract
Kocher, M. ; Heinzel, A. ; Mottaghy, F. M. ; et al
P01.01.A THE IMPACT OF BRAIN LESIONS ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH WHO CNS GRADE 3 OR 4 GLIOMA: A LESION-FUNCTION AND RESTING-STATE FMRI ANALYSIS
2023 18th Meeting of the European Association of Neuro-Oncology , RotterdamRotterdam, Netherlands, 21 Sep 2023 - 24 Sep 20232023-09-212023-09-24
(2023) [10.1093/neuonc/noad137.075]2023
BACKGROUNDIn glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL.MATERIAL AND METHODSIn 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. [...]
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2024-04-15 11:45 |
[FZJ-2024-02773]
Abstract
Friedrich, M. ; Stoffels, G. ; Filss, C. P. ; et al
P01.02.A WHOLE-BRAIN STRUCTURAL CONNECTIVITY PREDICTS COGNITIVE OUTCOMES IN PRETREATED PATIENTS WITH WHO GRADE 3 OR 4 GLIOMAS
202318th Meeting of the European Association of Neuro-Oncology , RotterdamRotterdam, Netherlands, 21 Sep 2023 - 24 Sep 20232023-09-212023-09-24
(2023) [10.1093/neuonc/noad137.076]2023
BACKGROUNDGlioma patients frequently suffer from cognitive dysfunction potentially related to brain damage caused by tumor invasion or therapeutic intervention. We hypothesized that, as in other neurological disorders, the long-term outcome of cognitive functions in glioma patients critically depends on maintaining the structural connectivity of multiple interconnected networks.PATIENTS AND METHODSOne hundred and twenty-one glioma patients (median age, 52 years; median ECOG score, 1) with histomolecularly characterized CNS WHO grade 3 or 4 gliomas were investigated after a median time of 14 months (range, 1-214 months) following first-line therapy, including resection and chemoradiation with alkylating agents. [...]
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2024-04-15 11:12 |
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2024-04-12 19:59 |
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2024-04-12 19:56 |
[FZJ-2024-02759]
Abstract
Kelly, M. S. ; Capelli, R. ; Kahawatte, S. ; et al
Optimizing biophysical predictor selection for katanin allosteric transitions via metadynamics and machine learning
2024Biophysical Society Meeting, PhiladelphiaPhiladelphia, USA, 10 Feb 2024 - 14 Feb 20242024-02-102024-02-14
(2024) [10.1016/j.bpj.2023.11.1698]2024
Katanin, a microtubule-severing enzyme, plays a pivotal role in regulating cytoskeletal dynamics, cell division, and intracellular transport. Katanin does this by forming a hexamer and undergoing a conformational change from its open “spiral” to closed “ring” state, which enacts mechanical forces required for the removal of tubulin dimers from the microtubule lattice. [...]
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2024-04-12 10:45 |
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2024-04-12 10:39 |
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2024-04-11 12:44 |
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2024-04-11 12:31 |
[FZJ-2024-02698]
Abstract
Baumeister, H. ; Wuestefeld, A. ; Adams, J. N. ; et al
Comparison of histological delineation of the entorhinal, perirhinal, ectorhinal, and parahippocampal cortices by different neuroanatomy laboratories
2023Alzheimer's Imaging Consortium, AmsterdamAmsterdam, Netherlands, 15 Jul 2023 - 15 Jul 20232023-07-152023-07-15
The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus,is crucial for memory and a hotspot of neurodegenerative processes (e.g.,accumulation of tau tangles or TDP-43). Importantly, theMTLcortex comprises severalsubregions with distinct functional, cytoarchitectonic, and macro-anatomical features(Fig. [...]
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2024-04-10 16:55 |
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