In process

AbstractMagnetic resonance imaging (MRI) is essential for post-treatment surveillance of patients with intracranial central nervous system (CNS) tumors. However, interpretation is often complicated due to post radiotherapy MRI abnormalities. [...]

Background: Hormonal fluctuations during the menstrual cycle (and their suppression) are accompanied by altered mood, cognition, and sleep, yet their relationship to subjective sleep quality and glymphatic function - a sleep- dependent brain waste-clearance pathway that involves perivascular spaces (PVS) - is unclear.Methods: We examined daily oestradiol, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), subjective sleep quality, and MRI-derived PVS volume (PVSV) in a single healthy woman across two 30-day periods: during her physiological menstrual cycle and, one year later, under oral contraceptive pill (OCP) use. We employed linear regression models to examine whether hormones are associated with sleep quality and PVSV, and whether they moderate the sleep quality-PVSV association during the physiological menstrual cycle [...]

Background Aggregation of amyloid-β (Aβ) and tau is central to Alzheimer’s disease (AD) pathogenesis and forms the basis of established cerebrospinal fluid (CSF) and imaging biomarkers. However, increasing evidence suggests that AD involves systemic processes beyond the central nervous system. [...]

230Th/234U chronometry on micro-scale particles is an emerging capability in nuclear safeguards that enables verification of past and present activities at nuclear facilities for consistency with national and international declarations. The implementation of 230Th/234U chronometry by large-geometry secondary ion mass spectrometry (LG-SIMS) requires well-characterised reference materials to quantify inter-element fractionation (Th/U relative sensitivity factor, RSF) at relevant abundance levels. [...]