In process

AbstractMagnetic resonance imaging (MRI) is essential for post-treatment surveillance of patients with intracranial central nervous system (CNS) tumors. However, interpretation is often complicated due to post radiotherapy MRI abnormalities. [...]

ABSTRACTAimsTo determine how lesion size and location shape longitudinal functional connectivity (FC) changes after stroke.MethodsAdult male mice underwent atlas‐based resting‐state fMRI at baseline and 1, 2, and 4 weeks after either a small photothrombotic cortical stroke (N = 25) or a larger transient cortico‐striatal MCAO stroke (N = 6). FC was quantified across 98 atlas regions, focusing on sensorimotor cortex, striatum, and thalamus, including intra‐ and inter‐hemispheric connectivity matrices and regional seed strength.ResultsCortical stroke caused widespread hyperconnectivity at Weeks 1–2, with about 90% of connections increased, followed by partial normalization by Week 4 [...]

No abstract availableKeywords: PET-based resection; amino acid..

ABSTRACTMotor responses are influenced by inferred predictability, but it remains unclear how uncertainty, or its inverse, precision,is encoded within motor control networks. In this study, we combined computational modeling of reaching movement responsespeed with functional magnetic resonance imaging (fMRI). [...]

AbstractBackground Aggregation of amyloid-β (Aβ) and tau is central to Alzheimer’s disease (AD) pathogenesis and formsthe basis of established cerebrospinal fluid (CSF) and imaging biomarkers. However, increasing evidence suggeststhat AD involves systemic processes beyond the central nervous system [...]

Background: Hormonal fluctuations during the menstrual cycle (and their suppression) are accompanied by altered mood, cognition, and sleep, yet their relationship to subjective sleep quality and glymphatic function - a sleep- dependent brain waste-clearance pathway that involves perivascular spaces (PVS) - is unclear.Methods: We examined daily oestradiol, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), subjective sleep quality, and MRI-derived PVS volume (PVSV) in a single healthy woman across two 30-day periods: during her physiological menstrual cycle and, one year later, under oral contraceptive pill (OCP) use. We employed linear regression models to examine whether hormones are associated with sleep quality and PVSV, and whether they moderate the sleep quality-PVSV association during the physiological menstrual cycle [...]

Background Aggregation of amyloid-β (Aβ) and tau is central to Alzheimer’s disease (AD) pathogenesis and forms the basis of established cerebrospinal fluid (CSF) and imaging biomarkers. However, increasing evidence suggests that AD involves systemic processes beyond the central nervous system. [...]