In process

It is assumed that amino acid PET positivity of gliomas corresponds to tracer uptake by tumor cells via the amino acid transporter heterodimer CD98, consisting of a light (LAT1) and heavy subunit (CD98hc), but correlative studies of human tumor tissue samples and PET imaging are largely lacking. Methods: We evaluated a series of 31 patients with diffuse glioma (18 IDH-mutant, 13 IDH-wild type), of whom preoperative amino acid PET images and corresponding tumor tissue samples were available. [...]

B R I E F R E P O R TWearable Movement-Tracking for Prodromal Parkinson’s DiseaseDetection: A Cross-Country Validation StudyFabian Kahl, MSc, 1 Ann-Kathrin Schalkamp, PhD,2,3,4 Katarina Mary Gunter, MSc, 5 Anja Ophey, PhD,6,7Sinah Röttgen, MSc, 7,8 Jamil Razzaque, MSc,5 Konstantin Kufer, MSc, 9,10 Cynthia Sandor, PhD,3,4Gereon R. Fink, MD, 7,8 Elke Kalbe, PhD,6 Walter Maetzler, MD, 11 Clint Hansen, PhD, 11 Stephan M [...]

Cross-frequency coupling (CFC) has been proposed to facilitate neural information transfer across spatial and temporal scales. Phase-amplitude coupling (PAC), a type of CFC in which the amplitude of a faster brain oscillation is coupled to the phase of a slower brain oscillation, is implicated in various higher-order cognitive functions and was shown to be pathologically altered in neurological and psychiatric disease. [...]

Isolated/idiopathic rapid-eye-movement (REM)-Sleep Behavior Disorder (iRBD) is characterized by dream enactment behaviors associated with loss of REM atonia. iRBD is in most cases a prodromal synucleinopathy, and emerging evidence suggests associations between RBD and other neurological and psychiatric conditions [...]

Beyond immediate neuronal damage, functional and structural connectivity is altered brain-wide with implications for functional deficits and recovery in stroke. It remains unclear, however, if the level of axonal damage, as well as compensatory plasticity, i.e., axonal sprouting and remyelination, depend on the lesion size and topology [...]