Journal Article

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2018-10-23
15:22
OpenAccess [FZJ-2018-05989] Journal Article
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Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl-/H+ Antiporter ClC-5
Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl-/H+ antiporter ClC-5. The disease typically manifests with proteinuria, hypercalciuria, nephrocalcinosis, and nephrolithiasis but is characterized by large phenotypic variability of no clear origin. [...]
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2018-10-23
14:47
OpenAccess [FZJ-2018-05987] Journal Article
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Au Nanoparticles as Template for Defect Formation in Memristive SrTiO3 Thin Films
Nanomaterials 8(11), 869 () [10.3390/nano8110869]
We investigated the possibility of tuning the local switching properties of memristive crystalline SrTiO 3 thin films by inserting nanoscale defect nucleation centers. For that purpose, we employed chemically-synthesized Au nanoparticles deposited on 0.5 wt%-Nb-doped SrTiO 3 single crystal substrates as a defect formation template for the subsequent growth of SrTiO 3 [...]
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2018-10-23
13:59
[FZJ-2018-05986] Journal Article
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The structural index of sensitivity equation systems
This work presents a new methodology for computing parameter sensitivities of differential algebraic system of equations with higher differential index. This methodology is particularly adequate for performing sensitivity analysis of object-oriented models described by modern universal modelling languages. [...]
ddc:510
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2018-10-23
13:55
[FZJ-2018-05985] Journal Article
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In Vitro Reconstitution of the Highly Active and Natively Folded Recombinant Human Superoxide Dismutase 1 Holoenzyme
ChemistrySelect 3(26), 7627 - 7632 () [10.1002/slct.201801319]
SOD1 is an antioxidant enzyme that exists as a highly stable dimer in healthy humans. Each subunit contains an intramolecular disulfide bond and coordinates one zinc and one copper ion. [...]
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2018-10-23
13:40
OpenAccess [FZJ-2018-05981] Journal Article
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Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
The protein α-Synuclein (αS) is linked to Parkinson’s disease through its abnormal aggregation, which is thought to involve cytosolic and membrane-bound forms of αS. Following previous studies using micelles and vesicles, we present a comprehensive study of αS interaction with phospholipid bilayer nanodiscs. [...]
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ddc:570
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2018-10-22
16:37
DBCoverage [FZJ-2018-05975] Journal Article
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Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study
Molecules 23(10), 2616 - () [10.3390/molecules23102616]
Human G-protein coupled receptors (GPCRs) are important targets for pharmaceutical intervention against neurological diseases. Here, we use molecular simulation to investigate the key step in ligand recognition governed by the extracellular domains in the neuronal adenosine receptor type 2A (hA2AR), a target for neuroprotective compounds. [...]
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2018-10-22
16:30
OpenAccess [FZJ-2018-05974] Journal Article
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Derivation of Fiber Orientations From Oblique Views Through Human Brain Sections in 3D-Polarized Light Imaging
3D-Polarized Light Imaging (3D-PLI) enables high-resolution three-dimensional mapping of the nerve fiber architecture in unstained histological brain sections based on the intrinsic birefringence of myelinated nerve fibers. The interpretation of the measured birefringent signals comes with conjointly measured information about the local fiber birefringence strength and the fiber orientation [...]
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2018-10-22
16:27
OpenAccess [FZJ-2018-05973] Journal Article
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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk [...]
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2018-10-22
16:24
[FZJ-2018-05972] Journal Article
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Differences in cytoarchitecture of Broca's region between human, ape and macaque brains.
Areas 44 and 45 have been identified in non-human primates as homologs of the human Broca region. Distribution of large and smaller pyramids and the ventro-lateral localization in the posterior frontal lobe enable their identification in non-human primates. [...]
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2018-10-22
16:18
OpenAccess [FZJ-2018-05971] Journal Article
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Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Ankyrin-3 (ANK3) is one of the few genes that have been consistently identified as associated with bipolar disorder by multiple genome-wide association studies. However, the exact molecular basis of the association remains unknown. [...]
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