% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schumer:1002272,
      author       = {Schumer, Maya C. and Chase, Henry W. and Rozovsky, Renata
                      and Eickhoff, Simon B. and Phillips, Mary L.},
      title        = {{P}refrontal, parietal, and limbic condition-dependent
                      differences in bipolar disorder: a large-scale meta-analysis
                      of functional neuroimaging studies},
      journal      = {Molecular psychiatry},
      volume       = {28},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2023-01254},
      pages        = {2826–2838},
      year         = {2023},
      abstract     = {Background: Over the past few decades, neuroimaging
                      research in Bipolar Disorder (BD) has identified neural
                      differences underlying cognitive and emotional processing.
                      However, substantial clinical and methodological
                      heterogeneity present across neuroimaging experiments
                      potentially hinders the identification of consistent neural
                      biomarkers of BD. This meta-analysis aims to comprehensively
                      reassess brain activation and connectivity in BD in order to
                      identify replicable differences that converge across and
                      within resting-state, cognitive, and emotional neuroimaging
                      experiments.Methods: Neuroimaging experiments (using fMRI,
                      PET, or arterial spin labeling) reporting whole-brain
                      results in adults with BD and controls published from
                      December 1999-June 18, 2019 were identified via PubMed
                      search. Coordinates showing significant activation and/or
                      connectivity differences between BD participants and
                      controls during resting-state, emotional, or cognitive tasks
                      were extracted. Four parallel, independent meta-analyses
                      were calculated using the revised activation likelihood
                      estimation algorithm: all experiment types, all
                      resting-state experiments, all cognitive experiments, and
                      all emotional experiments. To confirm reliability of
                      identified clusters, two different meta-analytic
                      significance tests were employed.Results: 205 published
                      studies yielding 506 individual neuroimaging experiments
                      (150 resting-state, 134 cognitive, 222 emotional) comprising
                      5745 BD and 8023 control participants were included. Five
                      regions survived both significance tests. Individuals with
                      BD showed functional differences in the right posterior
                      cingulate cortex during resting-state experiments, the left
                      amygdala during emotional experiments, including those using
                      a mixed (positive/negative) valence manipulation, and the
                      left superior and right inferior parietal lobules during
                      cognitive experiments, while hyperactivating the left medial
                      orbitofrontal cortex during cognitive experiments. Across
                      all experiments, there was convergence in the right caudate
                      extending to the ventral striatum, surviving only one
                      significance test.Conclusions: Our findings indicate
                      reproducible localization of prefrontal, parietal, and
                      limbic differences distinguishing BD from control
                      participants that are condition-dependent, despite
                      heterogeneity, and point towards a framework for identifying
                      reproducible differences in BD that may guide diagnosis and
                      treatment.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36782061},
      UT           = {WOS:000930456900004},
      doi          = {10.1038/s41380-023-01974-8},
      url          = {https://juser.fz-juelich.de/record/1002272},
}