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000010029 0247_ $$2pmid$$apmid:20349263
000010029 0247_ $$2DOI$$a10.1007/s00018-010-0350-6
000010029 0247_ $$2WOS$$aWOS:000279025400010
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000010029 041__ $$aeng
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000010029 084__ $$2WoS$$aBiochemistry & Molecular Biology
000010029 084__ $$2WoS$$aCell Biology
000010029 1001_ $$0P:(DE-Juel1)VDB92608$$aThamm, M.$$b0$$uFZJ
000010029 245__ $$aCharacterization of the 5-HT(1A) receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior
000010029 260__ $$aBasel$$bBirkhäuser$$c2010
000010029 300__ $$a2467 - 2479
000010029 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010029 440_0 $$01153$$aCellular and Molecular Life Sciences$$v67$$x1420-682X
000010029 500__ $$aWe thank J. Schlenstedt for initiating the work on the honeybee 5-HT<INF>1A</INF> receptor and J. Erber for supporting the phototaxis experiments. This work was supported by the German Science Foundation (Research Training Group 837 Functional Insect Science, scholarship to M.T.).
000010029 520__ $$aSerotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes. The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of a cDNA from the honeybee (Am5-ht1A) sharing high similarity with members of the 5-HT(1) receptor class. Activation of Am5-HT(1A) by serotonin inhibited the production of cAMP in a dose-dependent manner (EC(50) = 16.9 nM). Am5-HT(1A) was highly expressed in brain regions known to be involved in visual information processing. Using in vivo pharmacology, we could demonstrate that Am5-HT(1A) receptor ligands had a strong impact on the phototactic behavior of individual bees. The data presented here mark the first comprehensive study-from gene to behavior-of a 5-HT(1A) receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the physiology and behavior of this social insect.
000010029 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
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000010029 650_2 $$2MeSH$$aAmino Acid Sequence
000010029 650_2 $$2MeSH$$aAnimals
000010029 650_2 $$2MeSH$$aBees: metabolism
000010029 650_2 $$2MeSH$$aBees: physiology
000010029 650_2 $$2MeSH$$aBehavior, Animal: drug effects
000010029 650_2 $$2MeSH$$aBrain: metabolism
000010029 650_2 $$2MeSH$$aHumans
000010029 650_2 $$2MeSH$$aImmunohistochemistry
000010029 650_2 $$2MeSH$$aInsect Proteins: chemistry
000010029 650_2 $$2MeSH$$aInsect Proteins: genetics
000010029 650_2 $$2MeSH$$aInsect Proteins: immunology
000010029 650_2 $$2MeSH$$aInsect Proteins: metabolism
000010029 650_2 $$2MeSH$$aLigands
000010029 650_2 $$2MeSH$$aLight
000010029 650_2 $$2MeSH$$aMolecular Sequence Data
000010029 650_2 $$2MeSH$$aMovement: drug effects
000010029 650_2 $$2MeSH$$aMushroom Bodies: metabolism
000010029 650_2 $$2MeSH$$aOptic Lobe, Nonmammalian: metabolism
000010029 650_2 $$2MeSH$$aPrazosin: pharmacology
000010029 650_2 $$2MeSH$$aReceptor, Serotonin, 5-HT1A: chemistry
000010029 650_2 $$2MeSH$$aReceptor, Serotonin, 5-HT1A: genetics
000010029 650_2 $$2MeSH$$aReceptor, Serotonin, 5-HT1A: immunology
000010029 650_2 $$2MeSH$$aReceptor, Serotonin, 5-HT1A: metabolism
000010029 650_2 $$2MeSH$$aSerotonin: analogs & derivatives
000010029 650_2 $$2MeSH$$aSerotonin: metabolism
000010029 650_2 $$2MeSH$$aSerotonin: pharmacology
000010029 650_2 $$2MeSH$$aSerotonin Antagonists: pharmacology
000010029 650_2 $$2MeSH$$aSerotonin Receptor Agonists: pharmacology
000010029 650_7 $$00$$2NLM Chemicals$$aInsect Proteins
000010029 650_7 $$00$$2NLM Chemicals$$aLigands
000010029 650_7 $$00$$2NLM Chemicals$$aSerotonin Antagonists
000010029 650_7 $$00$$2NLM Chemicals$$aSerotonin Receptor Agonists
000010029 650_7 $$0112692-38-3$$2NLM Chemicals$$aReceptor, Serotonin, 5-HT1A
000010029 650_7 $$019216-56-9$$2NLM Chemicals$$aPrazosin
000010029 650_7 $$050-67-9$$2NLM Chemicals$$aSerotonin
000010029 650_7 $$074885-09-9$$2NLM Chemicals$$a5-carboxamidotryptamine
000010029 650_7 $$2WoSType$$aJ
000010029 65320 $$2Author$$a5-HT
000010029 65320 $$2Author$$aBiogenic amine
000010029 65320 $$2Author$$aCyclic AMP
000010029 65320 $$2Author$$aGPCR
000010029 65320 $$2Author$$aPhototaxis
000010029 65320 $$2Author$$aSignal transduction
000010029 7001_ $$0P:(DE-HGF)0$$aBalfanz, S.$$b1
000010029 7001_ $$0P:(DE-HGF)0$$aScheiner, R.$$b2
000010029 7001_ $$0P:(DE-HGF)0$$aBaumann, A.$$b3
000010029 7001_ $$0P:(DE-Juel1)VDB4899$$aBlenau, W.$$b4$$uFZJ
000010029 773__ $$0PERI:(DE-600)1458497-9$$a10.1007/s00018-010-0350-6$$gVol. 67, p. 2467 - 2479$$p2467 - 2479$$q67<2467 - 2479$$tCellular and molecular life sciences$$v67$$x1420-682X$$y2010
000010029 8567_ $$uhttp://dx.doi.org/10.1007/s00018-010-0350-6
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000010029 9141_ $$y2010
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000010029 9201_ $$0I:(DE-Juel1)VDB922$$gISB$$kISB-1$$lZelluläre Biophysik$$x0
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