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@ARTICLE{Thamm:10029,
      author       = {Thamm, M. and Balfanz, S. and Scheiner, R. and Baumann, A.
                      and Blenau, W.},
      title        = {{C}haracterization of the 5-{HT}(1{A}) receptor of the
                      honeybee ({A}pis mellifera) and involvement of serotonin in
                      phototactic behavior},
      journal      = {Cellular and molecular life sciences},
      volume       = {67},
      issn         = {1420-682X},
      address      = {Basel},
      publisher    = {Birkhäuser},
      reportid     = {PreJuSER-10029},
      pages        = {2467 - 2479},
      year         = {2010},
      note         = {We thank J. Schlenstedt for initiating the work on the
                      honeybee 5-HT<INF>1A</INF> receptor and J. Erber for
                      supporting the phototaxis experiments. This work was
                      supported by the German Science Foundation (Research
                      Training Group 837 Functional Insect Science, scholarship to
                      M.T.).},
      abstract     = {Serotonin plays a key role in modulating various
                      physiological and behavioral processes in both protostomes
                      and deuterostomes. The vast majority of serotonin receptors
                      belong to the superfamily of G-protein-coupled receptors. We
                      report the cloning of a cDNA from the honeybee (Am5-ht1A)
                      sharing high similarity with members of the 5-HT(1) receptor
                      class. Activation of Am5-HT(1A) by serotonin inhibited the
                      production of cAMP in a dose-dependent manner (EC(50) = 16.9
                      nM). Am5-HT(1A) was highly expressed in brain regions known
                      to be involved in visual information processing. Using in
                      vivo pharmacology, we could demonstrate that Am5-HT(1A)
                      receptor ligands had a strong impact on the phototactic
                      behavior of individual bees. The data presented here mark
                      the first comprehensive study-from gene to behavior-of a
                      5-HT(1A) receptor in the honeybee, paving the way for the
                      eventual elucidation of additional roles of this receptor
                      subtype in the physiology and behavior of this social
                      insect.},
      keywords     = {Amino Acid Sequence / Animals / Bees: metabolism / Bees:
                      physiology / Behavior, Animal: drug effects / Brain:
                      metabolism / Humans / Immunohistochemistry / Insect
                      Proteins: chemistry / Insect Proteins: genetics / Insect
                      Proteins: immunology / Insect Proteins: metabolism / Ligands
                      / Light / Molecular Sequence Data / Movement: drug effects /
                      Mushroom Bodies: metabolism / Optic Lobe, Nonmammalian:
                      metabolism / Prazosin: pharmacology / Receptor, Serotonin,
                      5-HT1A: chemistry / Receptor, Serotonin, 5-HT1A: genetics /
                      Receptor, Serotonin, 5-HT1A: immunology / Receptor,
                      Serotonin, 5-HT1A: metabolism / Serotonin: analogs $\&$
                      derivatives / Serotonin: metabolism / Serotonin:
                      pharmacology / Serotonin Antagonists: pharmacology /
                      Serotonin Receptor Agonists: pharmacology / Insect Proteins
                      (NLM Chemicals) / Ligands (NLM Chemicals) / Serotonin
                      Antagonists (NLM Chemicals) / Serotonin Receptor Agonists
                      (NLM Chemicals) / Receptor, Serotonin, 5-HT1A (NLM
                      Chemicals) / Prazosin (NLM Chemicals) / Serotonin (NLM
                      Chemicals) / 5-carboxamidotryptamine (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ISB-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB922},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Cell Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20349263},
      UT           = {WOS:000279025400010},
      doi          = {10.1007/s00018-010-0350-6},
      url          = {https://juser.fz-juelich.de/record/10029},
}