Home > Publications database > Characterization of the 5-HT(1A) receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior > print

001     10029
005     20200402205839.0
024 7 _ |2 pmid
|a pmid:20349263
024 7 _ |2 DOI
|a 10.1007/s00018-010-0350-6
024 7 _ |2 WOS
|a WOS:000279025400010
037 _ _ |a PreJuSER-10029
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Cell Biology
100 1 _ |a Thamm, M.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB92608
245 _ _ |a Characterization of the 5-HT(1A) receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior
260 _ _ |a Basel
|b Birkhäuser
|c 2010
300 _ _ |a 2467 - 2479
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Cellular and Molecular Life Sciences
|x 1420-682X
|0 1153
|v 67
500 _ _ |a We thank J. Schlenstedt for initiating the work on the honeybee 5-HT1A receptor and J. Erber for supporting the phototaxis experiments. This work was supported by the German Science Foundation (Research Training Group 837 Functional Insect Science, scholarship to M.T.).
520 _ _ |a Serotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes. The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of a cDNA from the honeybee (Am5-ht1A) sharing high similarity with members of the 5-HT(1) receptor class. Activation of Am5-HT(1A) by serotonin inhibited the production of cAMP in a dose-dependent manner (EC(50) = 16.9 nM). Am5-HT(1A) was highly expressed in brain regions known to be involved in visual information processing. Using in vivo pharmacology, we could demonstrate that Am5-HT(1A) receptor ligands had a strong impact on the phototactic behavior of individual bees. The data presented here mark the first comprehensive study-from gene to behavior-of a 5-HT(1A) receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the physiology and behavior of this social insect.
536 _ _ |a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
|c P45
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK505
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Amino Acid Sequence
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Bees: metabolism
650 _ 2 |2 MeSH
|a Bees: physiology
650 _ 2 |2 MeSH
|a Behavior, Animal: drug effects
650 _ 2 |2 MeSH
|a Brain: metabolism
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Immunohistochemistry
650 _ 2 |2 MeSH
|a Insect Proteins: chemistry
650 _ 2 |2 MeSH
|a Insect Proteins: genetics
650 _ 2 |2 MeSH
|a Insect Proteins: immunology
650 _ 2 |2 MeSH
|a Insect Proteins: metabolism
650 _ 2 |2 MeSH
|a Ligands
650 _ 2 |2 MeSH
|a Light
650 _ 2 |2 MeSH
|a Molecular Sequence Data
650 _ 2 |2 MeSH
|a Movement: drug effects
650 _ 2 |2 MeSH
|a Mushroom Bodies: metabolism
650 _ 2 |2 MeSH
|a Optic Lobe, Nonmammalian: metabolism
650 _ 2 |2 MeSH
|a Prazosin: pharmacology
650 _ 2 |2 MeSH
|a Receptor, Serotonin, 5-HT1A: chemistry
650 _ 2 |2 MeSH
|a Receptor, Serotonin, 5-HT1A: genetics
650 _ 2 |2 MeSH
|a Receptor, Serotonin, 5-HT1A: immunology
650 _ 2 |2 MeSH
|a Receptor, Serotonin, 5-HT1A: metabolism
650 _ 2 |2 MeSH
|a Serotonin: analogs & derivatives
650 _ 2 |2 MeSH
|a Serotonin: metabolism
650 _ 2 |2 MeSH
|a Serotonin: pharmacology
650 _ 2 |2 MeSH
|a Serotonin Antagonists: pharmacology
650 _ 2 |2 MeSH
|a Serotonin Receptor Agonists: pharmacology
650 _ 7 |0 0
|2 NLM Chemicals
|a Insect Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a Ligands
650 _ 7 |0 0
|2 NLM Chemicals
|a Serotonin Antagonists
650 _ 7 |0 0
|2 NLM Chemicals
|a Serotonin Receptor Agonists
650 _ 7 |0 112692-38-3
|2 NLM Chemicals
|a Receptor, Serotonin, 5-HT1A
650 _ 7 |0 19216-56-9
|2 NLM Chemicals
|a Prazosin
650 _ 7 |0 50-67-9
|2 NLM Chemicals
|a Serotonin
650 _ 7 |0 74885-09-9
|2 NLM Chemicals
|a 5-carboxamidotryptamine
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a 5-HT
653 2 0 |2 Author
|a Biogenic amine
653 2 0 |2 Author
|a Cyclic AMP
653 2 0 |2 Author
|a GPCR
653 2 0 |2 Author
|a Phototaxis
653 2 0 |2 Author
|a Signal transduction
700 1 _ |a Balfanz, S.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Scheiner, R.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Baumann, A.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Blenau, W.
|b 4
|u FZJ
|0 P:(DE-Juel1)VDB4899
773 _ _ |a 10.1007/s00018-010-0350-6
|g Vol. 67, p. 2467 - 2479
|p 2467 - 2479
|q 67<2467 - 2479
|0 PERI:(DE-600)1458497-9
|t Cellular and molecular life sciences
|v 67
|y 2010
|x 1420-682X
856 7 _ |u http://dx.doi.org/10.1007/s00018-010-0350-6
909 C O |o oai:juser.fz-juelich.de:10029
|p VDB
913 1 _ |k P45
|v BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
|l Biologische Informationsverarbeitung
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913 2 _ |a DE-HGF
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|l BioSoft Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
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|v Engineering Cell Function
|x 0
914 1 _ |y 2010
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k ISB-1
|l Zelluläre Biophysik
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980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBI-1-20200312
981 _ _ |a I:(DE-Juel1)ICS-4-20110106

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