001     1004183
005     20240226075522.0
024 7 _ |a 10.1101/2022.09.30.510304
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024 7 _ |a 2128/34186
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037 _ _ |a FZJ-2023-01295
100 1 _ |a Sasse, Leonard
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245 _ _ |a Intermediately Synchronised Brain States optimise trade-off between Subject Identifiability and Predictive Capacity
260 _ _ |c 2022
336 7 _ |a Preprint
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336 7 _ |a ARTICLE
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520 _ _ |a Functional connectivity (FC) refers to the statistical dependencies between activity of distinct brain areas. To study temporal fluctuations in FC within the duration of a functional magnetic resonance imaging (fMRI) scanning session, researchers have proposed the computation of an edge time series (ETS) and their derivatives. Evidence suggests that FC is driven by a few time points of high-amplitude co-fluctuation (HACF) in the ETS, which may also contribute disproportionately to interindividual differences. However, it remains unclear to what degree different time points actually contribute to brain-behaviour associations. Here, we systematically evaluate this question by assessing the predictive utility of FC estimates at different levels of co-fluctuation using machine learning (ML) approaches. We demonstrate that time points of lower and intermediate co-fluctuation levels provide overall highest subject specificity as well as highest predictive capacity of individual-level phenotypes.
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700 1 _ |a Larabi, Daouia I.
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700 1 _ |a Omidvarnia, Amir
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700 1 _ |a Jung, Kyesam
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700 1 _ |a Hoffstaedter, Felix
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700 1 _ |a Jocham, Gerhard
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700 1 _ |a Eickhoff, Simon B.
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700 1 _ |a Patil, Kaustubh R.
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|e Corresponding author
773 _ _ |a 10.1101/2022.09.30.510304
|y 2022
|t bioRxiv
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/1004183/files/2022.09.30.510304.docx
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/1004183/files/2022.09.30.510304.full-1.pdf
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