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001005158 1001_ $$0P:(DE-HGF)0$$aZare, Iman$$b0
001005158 245__ $$aGold nanostructures: synthesis, properties, and neurological applications
001005158 260__ $$aLondon$$bSoc.$$c2022
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001005158 520__ $$aRecent advances in technology are expected to increase our current understanding of neuroscience. Nanotechnology and nanomaterials can alter and control neural functionality in both in vitro and in vivo experimental setups. The intersection between neuroscience and nanoscience may generate long-term neural interfaces adapted at the molecular level. Owing to their intrinsic physicochemical characteristics, gold nanostructures (GNSs) have received much attention in neuroscience, especially for combined diagnostic and therapeutic (theragnostic) purposes. GNSs have been successfully employed to stimulate and monitor neurophysiological signals. Hence, GNSs could provide a promising solution for the regeneration and recovery of neural tissue, novel neuroprotective strategies, and integrated implantable materials. This review covers the broad range of neurological applications of GNS-based materials to improve clinical diagnosis and therapy. Sub-topics include neurotoxicity, targeted delivery of therapeutics to the central nervous system (CNS), neurochemical sensing, neuromodulation, neuroimaging, neurotherapy, tissue engineering, and neural regeneration. It focuses on core concepts of GNSs in neurology, to circumvent the limitations and significant obstacles of innovative approaches in neurobiology and neurochemistry, including theragnostics. We will discuss recent advances in the use of GNSs to overcome current bottlenecks and tackle technical and conceptual challenges.
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001005158 7001_ $$0P:(DE-HGF)0$$aYaraki, Mohammad Tavakkoli$$b1
001005158 7001_ $$0P:(DE-HGF)0$$aSperanza, Giorgio$$b2
001005158 7001_ $$0P:(DE-HGF)0$$aNajafabadi, Alireza Hassani$$b3
001005158 7001_ $$0P:(DE-HGF)0$$aShourangiz-Haghighi, Alireza$$b4
001005158 7001_ $$0P:(DE-HGF)0$$aNik, Amirala Bakhshian$$b5
001005158 7001_ $$0P:(DE-HGF)0$$aManshian, Bella B.$$b6
001005158 7001_ $$0P:(DE-HGF)0$$aSaraiva, Cláudia$$b7
001005158 7001_ $$0P:(DE-HGF)0$$aSoenen, Stefaan J.$$b8
001005158 7001_ $$0P:(DE-HGF)0$$aKogan, Marcelo J.$$b9
001005158 7001_ $$0P:(DE-HGF)0$$aLee, Jee Woong$$b10
001005158 7001_ $$0P:(DE-HGF)0$$aApollo, Nicholas V.$$b11
001005158 7001_ $$0P:(DE-HGF)0$$aBernardino, Liliana$$b12
001005158 7001_ $$0P:(DE-HGF)0$$aAraya, Eyleen$$b13
001005158 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b14$$eCorresponding author
001005158 7001_ $$0P:(DE-HGF)0$$aMao, Guangzhao$$b15
001005158 7001_ $$0P:(DE-HGF)0$$aHamblin, Michael R.$$b16
001005158 773__ $$0PERI:(DE-600)1472875-8$$a10.1039/D1CS01111A$$p2601-2680$$tChemical Society reviews$$v51$$x0306-0012$$y2022
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