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@ARTICLE{Parlak:1005494,
      author       = {Parlak, Zümray Vuslat and Labude-Weber, Norina and
                      Neuhaus, Kerstin and Schmidt, Christina and Morgan, Aaron
                      David and Zybała, Rafał and Gonzalez-Julian, Jesus and
                      Neuss, Sabine and Schickle, Karolina},
      title        = {{U}nveiling the main factors triggering the coagulation at
                      the {S}i{C} ‐blood interface},
      journal      = {Journal of biomedical materials research / A},
      volume       = {111},
      number       = {9},
      issn         = {0021-9304},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-01500},
      pages        = {1322-1332},
      year         = {2023},
      abstract     = {Hemocompatibility is the most significant criterion for
                      blood-contacting materials in successful in vivo
                      applications. Prior to the clinical tests, in vitro analyses
                      must be performed on the biomaterial surfaces in accordance
                      with the ISO 10993-4 standards. Designing a bio-functional
                      material requires engineering the surface structure and
                      chemistry, which significantly influence the blood cell
                      activity according to earlier studies. In this study, we
                      elucidate the role of surface terminations and polymorphs of
                      SiC single crystals in the initial stage of the contact
                      coagulation. We present a detailed analysis of phase,
                      roughness, surface potential, wettability, consequently,
                      reveal their effect on cytotoxicity and hemocompatibility by
                      employing live/dead stainings, live cell imaging, ELISA and
                      Micro BCA protein assay. Our results showed that the surface
                      potential and the wettability strongly depend on the
                      crystallographic polymorph as well as the surface
                      termination. We show, for the first time, the key role of
                      SiC surface termination on platelet activation. This
                      dependency is in good agreement with the results of our in
                      vitro analysis and points out the prominence of cellular
                      anisotropy. We anticipate that our experimental findings
                      bridge the surface properties to the cellular activities,
                      and therefore, pave the way for tailoring advanced
                      hemocompatible surfaces.},
      cin          = {IEK-12},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IEK-12-20141217},
      pnm          = {1221 - Fundamentals and Materials (POF4-122)},
      pid          = {G:(DE-HGF)POF4-1221},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36924189},
      UT           = {WOS:000952514900001},
      doi          = {10.1002/jbm.a.37533},
      url          = {https://juser.fz-juelich.de/record/1005494},
}