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001005639 1001_ $$0P:(DE-HGF)0$$aWeihs, Antoine$$b0
001005639 245__ $$aLack of structural brain alterations associated with insomnia: findings from the ENIGMA‐Sleep Working Group
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001005639 520__ $$aExisting neuroimaging studies have reported divergent structural alterations in insomnia disorder (ID). In the present study, we performed a large-scale coordinated meta-analysis by pooling structural brain measures from 1085 subjects (mean [SD] age 50.5 [13.9] years, 50.2% female, 17.4% with insomnia) across three international Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)-Sleep cohorts. Two sites recruited patients with ID/controls: Freiburg (University of Freiburg Medical Center, Freiburg, Germany) 42/43 and KUMS (Kermanshah University of Medical Sciences, Kermanshah, Iran) 42/49, while the Study of Health in Pomerania (SHIP-Trend, University Medicine Greifswald, Greifswald, Germany) recruited population-based individuals with/without insomnia symptoms 75/662. The influence of insomnia on magnetic resonance imaging-based brain morphometry using an insomnia brain score was then assessed. Within each cohort, we used an ordinary least-squares linear regression to investigate the link between the individual regional cortical and subcortical volumes and the presence of insomnia symptoms. Then, we performed a fixed-effects meta-analysis across cohorts based on the first-level results. For the insomnia brain score, weighted logistic ridge regression was performed on one sample (Freiburg), which separated patients with ID from controls to train a model based on the segmentation measurements. Afterward, the insomnia brain scores were validated using the other two samples. The model was used to predict the log-odds of the subjects with insomnia given individual insomnia-related brain atrophy. After adjusting for multiple comparisons, we did not detect any significant associations between insomnia symptoms and cortical or subcortical volumes, nor could we identify a global insomnia-related brain atrophy pattern. Thus, we observed inconsistent brain morphology differences between individuals with and without insomnia across three independent cohorts. Further large-scale cross-sectional/longitudinal studies using both structural and functional neuroimaging are warranted to decipher the neurobiology of insomnia.
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001005639 7001_ $$0P:(DE-HGF)0$$aFrenzel, Stefan$$b1
001005639 7001_ $$0P:(DE-Juel1)190453$$aBi, Hanwen$$b2$$ufzj
001005639 7001_ $$0P:(DE-HGF)0$$aSchiel, Julian E.$$b3
001005639 7001_ $$0P:(DE-HGF)0$$aAfshani, Mortaza$$b4
001005639 7001_ $$0P:(DE-HGF)0$$aBülow, Robin$$b5
001005639 7001_ $$0P:(DE-HGF)0$$aEwert, Ralf$$b6
001005639 7001_ $$0P:(DE-HGF)0$$aFietze, Ingo$$b7
001005639 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b8
001005639 7001_ $$0P:(DE-HGF)0$$aJahanshad, Neda$$b9
001005639 7001_ $$0P:(DE-HGF)0$$aKhazaie, Habibolah$$b10
001005639 7001_ $$0P:(DE-HGF)0$$aRiemann, Dieter$$b11
001005639 7001_ $$0P:(DE-HGF)0$$aRostampour, Masoumeh$$b12
001005639 7001_ $$0P:(DE-HGF)0$$aStubbe, Beate$$b13
001005639 7001_ $$0P:(DE-HGF)0$$aThomopoulos, Sophia I.$$b14
001005639 7001_ $$0P:(DE-HGF)0$$aThompson, Paul M.$$b15
001005639 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b16$$ufzj
001005639 7001_ $$0P:(DE-HGF)0$$aVölzke, Henry$$b17
001005639 7001_ $$0P:(DE-HGF)0$$aZarei, Mojtaba$$b18
001005639 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b19$$ufzj
001005639 7001_ $$0P:(DE-HGF)0$$aGrabe, Hans J.$$b20
001005639 7001_ $$0P:(DE-Juel1)172843$$aPatil, Kaustubh R.$$b21$$ufzj
001005639 7001_ $$0P:(DE-HGF)0$$aSpiegelhalder, Kai$$b22
001005639 7001_ $$0P:(DE-Juel1)188400$$aTahmasian, Masoud$$b23$$eCorresponding author
001005639 773__ $$0PERI:(DE-600)2007459-1$$a10.1111/jsr.13884$$n5$$pe13884$$tJournal of sleep research$$v32$$x0962-1105$$y2023
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