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@ARTICLE{Weihs:1005639,
      author       = {Weihs, Antoine and Frenzel, Stefan and Bi, Hanwen and
                      Schiel, Julian E. and Afshani, Mortaza and Bülow, Robin and
                      Ewert, Ralf and Fietze, Ingo and Hoffstaedter, Felix and
                      Jahanshad, Neda and Khazaie, Habibolah and Riemann, Dieter
                      and Rostampour, Masoumeh and Stubbe, Beate and Thomopoulos,
                      Sophia I. and Thompson, Paul M. and Valk, Sofie L. and
                      Völzke, Henry and Zarei, Mojtaba and Eickhoff, Simon B. and
                      Grabe, Hans J. and Patil, Kaustubh R. and Spiegelhalder, Kai
                      and Tahmasian, Masoud},
      title        = {{L}ack of structural brain alterations associated with
                      insomnia: findings from the {ENIGMA}‐{S}leep {W}orking
                      {G}roup},
      journal      = {Journal of sleep research},
      volume       = {32},
      number       = {5},
      issn         = {0962-1105},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2023-01582},
      pages        = {e13884},
      year         = {2023},
      abstract     = {Existing neuroimaging studies have reported divergent
                      structural alterations in insomnia disorder (ID). In the
                      present study, we performed a large-scale coordinated
                      meta-analysis by pooling structural brain measures from 1085
                      subjects (mean [SD] age 50.5 [13.9] years, $50.2\%$ female,
                      $17.4\%$ with insomnia) across three international Enhancing
                      NeuroImaging Genetics through Meta-Analysis (ENIGMA)-Sleep
                      cohorts. Two sites recruited patients with ID/controls:
                      Freiburg (University of Freiburg Medical Center, Freiburg,
                      Germany) 42/43 and KUMS (Kermanshah University of Medical
                      Sciences, Kermanshah, Iran) 42/49, while the Study of Health
                      in Pomerania (SHIP-Trend, University Medicine Greifswald,
                      Greifswald, Germany) recruited population-based individuals
                      with/without insomnia symptoms 75/662. The influence of
                      insomnia on magnetic resonance imaging-based brain
                      morphometry using an insomnia brain score was then assessed.
                      Within each cohort, we used an ordinary least-squares linear
                      regression to investigate the link between the individual
                      regional cortical and subcortical volumes and the presence
                      of insomnia symptoms. Then, we performed a fixed-effects
                      meta-analysis across cohorts based on the first-level
                      results. For the insomnia brain score, weighted logistic
                      ridge regression was performed on one sample (Freiburg),
                      which separated patients with ID from controls to train a
                      model based on the segmentation measurements. Afterward, the
                      insomnia brain scores were validated using the other two
                      samples. The model was used to predict the log-odds of the
                      subjects with insomnia given individual insomnia-related
                      brain atrophy. After adjusting for multiple comparisons, we
                      did not detect any significant associations between insomnia
                      symptoms and cortical or subcortical volumes, nor could we
                      identify a global insomnia-related brain atrophy pattern.
                      Thus, we observed inconsistent brain morphology differences
                      between individuals with and without insomnia across three
                      independent cohorts. Further large-scale
                      cross-sectional/longitudinal studies using both structural
                      and functional neuroimaging are warranted to decipher the
                      neurobiology of insomnia.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36944539},
      UT           = {WOS:000954145300001},
      doi          = {10.1111/jsr.13884},
      url          = {https://juser.fz-juelich.de/record/1005639},
}