% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Gtz:1005760,
      author       = {Götz, Jan and Wieters, Frederique and Fritz, Veronika J.
                      and Käsgen, Olivia and Kalantari, Aref and Fink, Gereon
                      Rudolf and Aswendt, Markus},
      title        = {{T}emporal and {S}patial {G}ene {E}xpression {P}rofile of
                      {S}troke {R}ecovery {G}enes in {M}ice},
      journal      = {Genes},
      volume       = {14},
      number       = {2},
      issn         = {2073-4425},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2023-01614},
      pages        = {454 -},
      year         = {2023},
      abstract     = {Stroke patients show some degree of spontaneous functional
                      recovery, but this is not sufficient to prevent long-term
                      disability. One promising approach is to characterize the
                      dynamics of stroke recovery genes in the lesion and distant
                      areas. We induced sensorimotor cortex lesions in adult
                      C57BL/6J mice using photothrombosis and performed qPCR on
                      selected brain areas at 14, 28, and 56 days post-stroke
                      (P14-56). Based on the grid walk and rotating beam test, the
                      mice were classified into two groups. The expression of cAMP
                      pathway genes Adora2a, Pde10a, and Drd2, was higher in poor-
                      compared to well-recovered mice in contralesional primary
                      motor cortex (cl-MOp) at $P14\&56$ and cl-thalamus (cl-TH),
                      but lower in cl-striatum (cl-Str) at P14 and cl-primary
                      somatosensory cortex (cl-SSp) at P28. Plasticity and axonal
                      sprouting genes, Lingo1 and BDNF, were decreased in cl-MOp
                      at P14 and cl-Str at P28 and increased in cl-SSp at P28 and
                      cl-Str at P14, respectively. In the cl-TH, Lingo1 was
                      increased, and BDNF decreased at P14. Atrx, also involved in
                      axonal sprouting, was only increased in poor-recovered mice
                      in cl-MOp at P28. The results underline the gene expression
                      dynamics and spatial variability and challenge existing
                      theories of restricted neural plasticity.Keywords: behavior;
                      cAMP pathway; grid walk; qPCR; recovery rate; rotating beam
                      test.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36833381},
      UT           = {WOS:000939287700001},
      doi          = {10.3390/genes14020454},
      url          = {https://juser.fz-juelich.de/record/1005760},
}