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| Hauptseite > Publikationsdatenbank > Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice > print |
| Hauptseite > Publikationsdatenbank > Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice > print |
| 001 | 1005760 | ||
| 005 | 20240129202806.0 | ||
| 024 | 7 | _ | |a 10.3390/genes14020454 |2 doi |
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| 100 | 1 | _ | |a Götz, Jan |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice |
| 260 | _ | _ | |a Basel |c 2023 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Stroke patients show some degree of spontaneous functional recovery, but this is not sufficient to prevent long-term disability. One promising approach is to characterize the dynamics of stroke recovery genes in the lesion and distant areas. We induced sensorimotor cortex lesions in adult C57BL/6J mice using photothrombosis and performed qPCR on selected brain areas at 14, 28, and 56 days post-stroke (P14-56). Based on the grid walk and rotating beam test, the mice were classified into two groups. The expression of cAMP pathway genes Adora2a, Pde10a, and Drd2, was higher in poor- compared to well-recovered mice in contralesional primary motor cortex (cl-MOp) at P14&56 and cl-thalamus (cl-TH), but lower in cl-striatum (cl-Str) at P14 and cl-primary somatosensory cortex (cl-SSp) at P28. Plasticity and axonal sprouting genes, Lingo1 and BDNF, were decreased in cl-MOp at P14 and cl-Str at P28 and increased in cl-SSp at P28 and cl-Str at P14, respectively. In the cl-TH, Lingo1 was increased, and BDNF decreased at P14. Atrx, also involved in axonal sprouting, was only increased in poor-recovered mice in cl-MOp at P28. The results underline the gene expression dynamics and spatial variability and challenge existing theories of restricted neural plasticity.Keywords: behavior; cAMP pathway; grid walk; qPCR; recovery rate; rotating beam test. |
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| 536 | _ | _ | |a DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) |0 G:(GEPRIS)431549029 |c 431549029 |x 1 |
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| 773 | _ | _ | |a 10.3390/genes14020454 |g Vol. 14, no. 2, p. 454 - |0 PERI:(DE-600)2527218-4 |n 2 |p 454 - |t Genes |v 14 |y 2023 |x 2073-4425 |
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