%0 Journal Article
%A Jost, Stefanie T.
%A Konitsioti, Agni
%A Loehrer, Philipp A.
%A Ashkan, Keyoumars
%A Rizos, Alexandra
%A Sauerbier, Anna
%A dos Santos Ghilardi, Maria Gabriela
%A Rosenkranz, Franz
%A Strobel, Lena
%A Gronostay, Alexandra
%A Barbe, Michael T.
%A Evans, Julian
%A Visser-Vandewalle, Veerle
%A Nimsky, Christopher
%A Fink, Gereon Rudolf
%A Silverdale, Monty
%A Cury, Rubens G.
%A Fonoff, Erich T.
%A Antonini, Angelo
%A Chaudhuri, K. Ray
%A Timmermann, Lars
%A Martinez-Martin, Pablo
%A Dafsari, Haidar S.
%T Non-motor effects of deep brain stimulation in Parkinson's disease motor subtypes
%J Parkinsonism & related disorders
%V 109
%@ 1353-8020
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2023-01615
%P 105318 -
%D 2023
%X Introduction: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD.Methods: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD). We analysed within-group longitudinal changes with Wilcoxon signed-rank test and Benjamini-Hochberg correction for multiple comparisons. Additionally, we explored outcome between-group differences of motor subtypes with Mann-Whitney U-tests.Results: In 82 PIGD and 33 tremor-dominant patients included in this study, baseline NMSS total scores were worse in PIGD patients, both groups experienced postoperative improvements of the NMSS sleep/fatigue domain, and between-group differences in postoperative outcomes were favourable in the PIGD group for the NMSS total and miscellaneous domain scores.Conclusions: This study provides evidence of a favourable outcome of total non-motor burden in PIGD compared to tremor-dominant patients undergoing DBS for PD. These differences of clinical efficacy on non-motor aspects should be considered when advising and monitoring patients with PD undergoing DBS.Keywords: Deep brain stimulation; Nonmotor symptoms; Postural instability and gait difficulty; Quality of life; Tremor-dominant.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36842866
%U <Go to ISI:>//WOS:000966739300001
%R 10.1016/j.parkreldis.2023.105318
%U https://juser.fz-juelich.de/record/1005761