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001005761 1001_ $$00000-0003-0477-2289$$aJost, Stefanie T.$$b0$$eCorresponding author
001005761 245__ $$aNon-motor effects of deep brain stimulation in Parkinson's disease motor subtypes
001005761 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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001005761 520__ $$aIntroduction: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD.Methods: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD). We analysed within-group longitudinal changes with Wilcoxon signed-rank test and Benjamini-Hochberg correction for multiple comparisons. Additionally, we explored outcome between-group differences of motor subtypes with Mann-Whitney U-tests.Results: In 82 PIGD and 33 tremor-dominant patients included in this study, baseline NMSS total scores were worse in PIGD patients, both groups experienced postoperative improvements of the NMSS sleep/fatigue domain, and between-group differences in postoperative outcomes were favourable in the PIGD group for the NMSS total and miscellaneous domain scores.Conclusions: This study provides evidence of a favourable outcome of total non-motor burden in PIGD compared to tremor-dominant patients undergoing DBS for PD. These differences of clinical efficacy on non-motor aspects should be considered when advising and monitoring patients with PD undergoing DBS.Keywords: Deep brain stimulation; Nonmotor symptoms; Postural instability and gait difficulty; Quality of life; Tremor-dominant.
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001005761 536__ $$0G:(GEPRIS)431549029$$aDFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x1
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001005761 7001_ $$aKonitsioti, Agni$$b1
001005761 7001_ $$00000-0002-5279-2156$$aLoehrer, Philipp A.$$b2
001005761 7001_ $$aAshkan, Keyoumars$$b3
001005761 7001_ $$aRizos, Alexandra$$b4
001005761 7001_ $$0P:(DE-HGF)0$$aSauerbier, Anna$$b5
001005761 7001_ $$ados Santos Ghilardi, Maria Gabriela$$b6
001005761 7001_ $$aRosenkranz, Franz$$b7
001005761 7001_ $$aStrobel, Lena$$b8
001005761 7001_ $$aGronostay, Alexandra$$b9
001005761 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b10
001005761 7001_ $$aEvans, Julian$$b11
001005761 7001_ $$aVisser-Vandewalle, Veerle$$b12
001005761 7001_ $$aNimsky, Christopher$$b13
001005761 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b14$$ufzj
001005761 7001_ $$00000-0002-3295-6897$$aSilverdale, Monty$$b15
001005761 7001_ $$00000-0001-6305-3327$$aCury, Rubens G.$$b16
001005761 7001_ $$aFonoff, Erich T.$$b17
001005761 7001_ $$00000-0003-1040-2807$$aAntonini, Angelo$$b18
001005761 7001_ $$aChaudhuri, K. Ray$$b19
001005761 7001_ $$aTimmermann, Lars$$b20
001005761 7001_ $$00000-0003-0837-5280$$aMartinez-Martin, Pablo$$b21
001005761 7001_ $$0P:(DE-HGF)0$$aDafsari, Haidar S.$$b22
001005761 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2023.105318$$gVol. 109, p. 105318 -$$p105318 -$$tParkinsonism & related disorders$$v109$$x1353-8020$$y2023
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