TY  - JOUR
AU  - Jost, Stefanie T.
AU  - Konitsioti, Agni
AU  - Loehrer, Philipp A.
AU  - Ashkan, Keyoumars
AU  - Rizos, Alexandra
AU  - Sauerbier, Anna
AU  - dos Santos Ghilardi, Maria Gabriela
AU  - Rosenkranz, Franz
AU  - Strobel, Lena
AU  - Gronostay, Alexandra
AU  - Barbe, Michael T.
AU  - Evans, Julian
AU  - Visser-Vandewalle, Veerle
AU  - Nimsky, Christopher
AU  - Fink, Gereon Rudolf
AU  - Silverdale, Monty
AU  - Cury, Rubens G.
AU  - Fonoff, Erich T.
AU  - Antonini, Angelo
AU  - Chaudhuri, K. Ray
AU  - Timmermann, Lars
AU  - Martinez-Martin, Pablo
AU  - Dafsari, Haidar S.
TI  - Non-motor effects of deep brain stimulation in Parkinson's disease motor subtypes
JO  - Parkinsonism & related disorders
VL  - 109
SN  - 1353-8020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2023-01615
SP  - 105318 -
PY  - 2023
AB  - Introduction: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD.Methods: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD). We analysed within-group longitudinal changes with Wilcoxon signed-rank test and Benjamini-Hochberg correction for multiple comparisons. Additionally, we explored outcome between-group differences of motor subtypes with Mann-Whitney U-tests.Results: In 82 PIGD and 33 tremor-dominant patients included in this study, baseline NMSS total scores were worse in PIGD patients, both groups experienced postoperative improvements of the NMSS sleep/fatigue domain, and between-group differences in postoperative outcomes were favourable in the PIGD group for the NMSS total and miscellaneous domain scores.Conclusions: This study provides evidence of a favourable outcome of total non-motor burden in PIGD compared to tremor-dominant patients undergoing DBS for PD. These differences of clinical efficacy on non-motor aspects should be considered when advising and monitoring patients with PD undergoing DBS.Keywords: Deep brain stimulation; Nonmotor symptoms; Postural instability and gait difficulty; Quality of life; Tremor-dominant.
LB  - PUB:(DE-HGF)16
C6  - 36842866
UR  - <Go to ISI:>//WOS:000966739300001
DO  - DOI:10.1016/j.parkreldis.2023.105318
UR  - https://juser.fz-juelich.de/record/1005761
ER  -