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@ARTICLE{Jost:1005761,
      author       = {Jost, Stefanie T. and Konitsioti, Agni and Loehrer, Philipp
                      A. and Ashkan, Keyoumars and Rizos, Alexandra and Sauerbier,
                      Anna and dos Santos Ghilardi, Maria Gabriela and Rosenkranz,
                      Franz and Strobel, Lena and Gronostay, Alexandra and Barbe,
                      Michael T. and Evans, Julian and Visser-Vandewalle, Veerle
                      and Nimsky, Christopher and Fink, Gereon Rudolf and
                      Silverdale, Monty and Cury, Rubens G. and Fonoff, Erich T.
                      and Antonini, Angelo and Chaudhuri, K. Ray and Timmermann,
                      Lars and Martinez-Martin, Pablo and Dafsari, Haidar S.},
      title        = {{N}on-motor effects of deep brain stimulation in
                      {P}arkinson's disease motor subtypes},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {109},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2023-01615},
      pages        = {105318 -},
      year         = {2023},
      abstract     = {Introduction: Deep brain stimulation (DBS) is a
                      well-established treatment for patients with Parkinson's
                      disease (PD) improving quality of life, motor, and non-motor
                      symptoms. However, non-motor effects in PD subtypes are
                      understudied. We hypothesized that patients with 'postural
                      instability and gait difficulty' (PIGD) experience more
                      beneficial non-motor effects than 'tremor-dominant' patients
                      undergoing DBS for PD.Methods: In this prospective,
                      observational, international multicentre study with a
                      6-month follow-up, we assessed the Non-Motor Symptom Scale
                      (NMSS) as primary and the following secondary outcomes:
                      Unified PD Rating Scale-motor examination (UPDRS-III),
                      Scales for Outcomes in PD (SCOPA)-activities of daily living
                      (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8),
                      and levodopa-equivalent daily dose (LEDD). We analysed
                      within-group longitudinal changes with Wilcoxon signed-rank
                      test and Benjamini-Hochberg correction for multiple
                      comparisons. Additionally, we explored outcome between-group
                      differences of motor subtypes with Mann-Whitney
                      U-tests.Results: In 82 PIGD and 33 tremor-dominant patients
                      included in this study, baseline NMSS total scores were
                      worse in PIGD patients, both groups experienced
                      postoperative improvements of the NMSS sleep/fatigue domain,
                      and between-group differences in postoperative outcomes were
                      favourable in the PIGD group for the NMSS total and
                      miscellaneous domain scores.Conclusions: This study provides
                      evidence of a favourable outcome of total non-motor burden
                      in PIGD compared to tremor-dominant patients undergoing DBS
                      for PD. These differences of clinical efficacy on non-motor
                      aspects should be considered when advising and monitoring
                      patients with PD undergoing DBS.Keywords: Deep brain
                      stimulation; Nonmotor symptoms; Postural instability and
                      gait difficulty; Quality of life; Tremor-dominant.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36842866},
      UT           = {WOS:000966739300001},
      doi          = {10.1016/j.parkreldis.2023.105318},
      url          = {https://juser.fz-juelich.de/record/1005761},
}