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| 001 | 1005761 | ||
| 005 | 20240129202806.0 | ||
| 024 | 7 | _ | |a 10.1016/j.parkreldis.2023.105318 |2 doi |
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| 100 | 1 | _ | |a Jost, Stefanie T. |0 0000-0003-0477-2289 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Non-motor effects of deep brain stimulation in Parkinson's disease motor subtypes |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2023 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1706531446_27505 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Introduction: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD.Methods: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and -motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD). We analysed within-group longitudinal changes with Wilcoxon signed-rank test and Benjamini-Hochberg correction for multiple comparisons. Additionally, we explored outcome between-group differences of motor subtypes with Mann-Whitney U-tests.Results: In 82 PIGD and 33 tremor-dominant patients included in this study, baseline NMSS total scores were worse in PIGD patients, both groups experienced postoperative improvements of the NMSS sleep/fatigue domain, and between-group differences in postoperative outcomes were favourable in the PIGD group for the NMSS total and miscellaneous domain scores.Conclusions: This study provides evidence of a favourable outcome of total non-motor burden in PIGD compared to tremor-dominant patients undergoing DBS for PD. These differences of clinical efficacy on non-motor aspects should be considered when advising and monitoring patients with PD undergoing DBS.Keywords: Deep brain stimulation; Nonmotor symptoms; Postural instability and gait difficulty; Quality of life; Tremor-dominant. |
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| 536 | _ | _ | |a DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) |0 G:(GEPRIS)431549029 |c 431549029 |x 1 |
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| 700 | 1 | _ | |a Konitsioti, Agni |b 1 |
| 700 | 1 | _ | |a Loehrer, Philipp A. |0 0000-0002-5279-2156 |b 2 |
| 700 | 1 | _ | |a Ashkan, Keyoumars |b 3 |
| 700 | 1 | _ | |a Rizos, Alexandra |b 4 |
| 700 | 1 | _ | |a Sauerbier, Anna |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a dos Santos Ghilardi, Maria Gabriela |b 6 |
| 700 | 1 | _ | |a Rosenkranz, Franz |b 7 |
| 700 | 1 | _ | |a Strobel, Lena |b 8 |
| 700 | 1 | _ | |a Gronostay, Alexandra |b 9 |
| 700 | 1 | _ | |a Barbe, Michael T. |0 P:(DE-Juel1)131613 |b 10 |
| 700 | 1 | _ | |a Evans, Julian |b 11 |
| 700 | 1 | _ | |a Visser-Vandewalle, Veerle |b 12 |
| 700 | 1 | _ | |a Nimsky, Christopher |b 13 |
| 700 | 1 | _ | |a Fink, Gereon Rudolf |0 P:(DE-Juel1)131720 |b 14 |u fzj |
| 700 | 1 | _ | |a Silverdale, Monty |0 0000-0002-3295-6897 |b 15 |
| 700 | 1 | _ | |a Cury, Rubens G. |0 0000-0001-6305-3327 |b 16 |
| 700 | 1 | _ | |a Fonoff, Erich T. |b 17 |
| 700 | 1 | _ | |a Antonini, Angelo |0 0000-0003-1040-2807 |b 18 |
| 700 | 1 | _ | |a Chaudhuri, K. Ray |b 19 |
| 700 | 1 | _ | |a Timmermann, Lars |b 20 |
| 700 | 1 | _ | |a Martinez-Martin, Pablo |0 0000-0003-0837-5280 |b 21 |
| 700 | 1 | _ | |a Dafsari, Haidar S. |0 P:(DE-HGF)0 |b 22 |
| 773 | _ | _ | |a 10.1016/j.parkreldis.2023.105318 |g Vol. 109, p. 105318 - |0 PERI:(DE-600)2027635-7 |p 105318 - |t Parkinsonism & related disorders |v 109 |y 2023 |x 1353-8020 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1005761/files/PDF%20nicht%20open%20access%20.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1005761/files/post-print.docx.pdf |y Published on 2023-02-09. Available in OpenAccess from 2024-02-09. |
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