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001005763 0247_ $$2doi$$a10.1002/mus.27813
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001005763 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-01617
001005763 0247_ $$2pmid$$a36905193
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001005763 1001_ $$00000-0002-9076-4236$$aSchneider, Christian$$b0$$eCorresponding author
001005763 245__ $$aSubclinical motor involvement in nonsystemic vasculitic neuropathy determined by the motor unit number estimation method MScanFit
001005763 260__ $$aNew York, NY [u.a.]$$bWiley$$c2023
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001005763 520__ $$aAbstract: Introduction/Aims:Nonsystemic vasculitic neuropathy(NSVN) is characterized by a pre-dominant lower limb involvement in many patients. Motor unit changes in upper extremitymuscles have not been investigated in this subgroup but may be of interest for improvingour understanding of the multifocal nature of the disease and counseling of patients aboutpotential future symptoms. In this study we aimed to better understand subclinical motorinvolvement in the upper extremity muscles of patients with lower limb–predominantNSVN using the new motor unit number estimation (MUNE) method MScanFit.Methods:In this single-center, cross-sectionalstudy, 14 patients with biopsy-provenNSVN, with no clinical signs of upper extremity motor involvement, were investigatedand compared with 14 age-matched healthy controls. All participants were assessed clini-cally and by the MUNE method MScanFit tothe abductor pollicis brevis muscle.Results:The number of motor units and peak CMAP amplitudes were significantlyreduced in patients with NSVN (P=.003 andP=.004, respectively). Absolutemedian motor unit amplitudes and CMAP discontinuities were not significantly dif-ferent (P=.246 andP=.1, respectively). CMAP discontinuities were not signifi-cantly correlated with motor unit loss (P=.15, rho=0.4). The number of motorunits did not correlate with clinical scores (P=.77, rho=0.082).Discussion:Both MUNE and CMAP amplitudes showed motor involvement in upperextremity muscles in lower limb–predominant NSVN. Overall, there was no evidenceof significant reinnervation. Investigations of the abductor pollicis brevis muscle didnot show a correlation with overall functional disability of the patients.KEYWORDSmotor unit number estimation, MScanFit, polyneuropathy, vasculitic neuropathy, vasculitis
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001005763 7001_ $$0P:(DE-HGF)0$$aWassermann, Meike K.$$b1
001005763 7001_ $$0P:(DE-HGF)0$$aSvačina, Martin K. R.$$b2
001005763 7001_ $$00000-0001-5544-335X$$aWunderlich, Gilbert$$b3
001005763 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b4
001005763 7001_ $$0P:(DE-HGF)0$$aLehmann, Helmar C.$$b5
001005763 773__ $$0PERI:(DE-600)1476641-3$$a10.1002/mus.27813$$gp. mus.27813$$n6$$p474-480$$tMuscle & nerve$$v67$$x0148-639X$$y2023
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