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@ARTICLE{Schneider:1005763,
      author       = {Schneider, Christian and Wassermann, Meike K. and Svačina,
                      Martin K. R. and Wunderlich, Gilbert and Fink, Gereon R. and
                      Lehmann, Helmar C.},
      title        = {{S}ubclinical motor involvement in nonsystemic vasculitic
                      neuropathy determined by the motor unit number estimation
                      method {MS}can{F}it},
      journal      = {Muscle $\&$ nerve},
      volume       = {67},
      number       = {6},
      issn         = {0148-639X},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-01617},
      pages        = {474-480},
      year         = {2023},
      abstract     = {Abstract: Introduction/Aims:Nonsystemic vasculitic
                      neuropathy(NSVN) is characterized by a pre-dominant lower
                      limb involvement in many patients. Motor unit changes in
                      upper extremitymuscles have not been investigated in this
                      subgroup but may be of interest for improvingour
                      understanding of the multifocal nature of the disease and
                      counseling of patients aboutpotential future symptoms. In
                      this study we aimed to better understand subclinical
                      motorinvolvement in the upper extremity muscles of patients
                      with lower limb–predominantNSVN using the new motor unit
                      number estimation (MUNE) method MScanFit.Methods:In this
                      single-center, cross-sectionalstudy, 14 patients with
                      biopsy-provenNSVN, with no clinical signs of upper extremity
                      motor involvement, were investigatedand compared with 14
                      age-matched healthy controls. All participants were assessed
                      clini-cally and by the MUNE method MScanFit tothe abductor
                      pollicis brevis muscle.Results:The number of motor units and
                      peak CMAP amplitudes were significantlyreduced in patients
                      with NSVN (P=.003 andP=.004, respectively). Absolutemedian
                      motor unit amplitudes and CMAP discontinuities were not
                      significantly dif-ferent (P=.246 andP=.1, respectively).
                      CMAP discontinuities were not signifi-cantly correlated with
                      motor unit loss (P=.15, rho=0.4). The number of motorunits
                      did not correlate with clinical scores (P=.77,
                      rho=0.082).Discussion:Both MUNE and CMAP amplitudes showed
                      motor involvement in upperextremity muscles in lower
                      limb–predominant NSVN. Overall, there was no evidenceof
                      significant reinnervation. Investigations of the abductor
                      pollicis brevis muscle didnot show a correlation with
                      overall functional disability of the patients.KEYWORDSmotor
                      unit number estimation, MScanFit, polyneuropathy, vasculitic
                      neuropathy, vasculitis},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36905193},
      UT           = {WOS:000951731600001},
      doi          = {10.1002/mus.27813},
      url          = {https://juser.fz-juelich.de/record/1005763},
}