TY  - JOUR
AU  - Li, Yongqiang
AU  - Shi, Zhifeng
AU  - Shang, Liuyang
AU  - Tao, Quan
AU  - Tang, Qisheng
AU  - Krause, Hans-Joachim
AU  - Yang, Siwei
AU  - Ding, Guqiao
AU  - Dong, Hui
TI  - Graphene quantum dots-based magnetic relaxation switch involving magnetic separation for enhanced performances of endoglin detection using ultra-low-field nuclear magnetic resonance relaxometry
JO  - Sensors and actuators  / B
VL  - 380
SN  - 0925-4005
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2023-01641
SP  - 133389 -
PY  - 2023
AB  - Magnetic relaxation switches (MRS) based on target-induced state changes of magnetic nanoparticles are vital approaches for biomolecule detection in in vitro diagnosis. Recently, magnetic graphene quantum dots have been employed as magnetic probes instead of iron oxide nanoparticles and showed high sensitivity. Introducing magnetic separation into an MRS assay before the relaxometry measurements can enhance the sensitivity, elevateaccuracy, and expand the linear region. In this work, magnetic separation-assisted MRS was developed to detect endoglin utilizing iron oxide as the magnetic carrier and magnetic graphene quantum dots as the magnetic probe. The assay possesses a broad linear region from 5 ng/mL to 50 μg/mL and a sensitive limit of detection of 1.3 ng/mL, which is two orders of magnitude lower than that of MRS without magnetic separation. The high accuracy and consistency have been proved for endoglin (CD105) detection in real samples. This graphene quantum dotbased MRS involving magnetic separation provides a new route for enhancing the sensitivity and accuracy of biomolecule detection.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000979418700001
DO  - DOI:10.1016/j.snb.2023.133389
UR  - https://juser.fz-juelich.de/record/1005796
ER  -