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@ARTICLE{Capone:1006405,
author = {Capone, Cristiano and De Luca, Chiara and De Bonis, Giulia
and Gutzen, Robin and Bernava, Irene and Pastorelli, Elena
and Simula, Francesco and Lupo, Cosimo and Tonielli,
Leonardo and Resta, Francesco and Allegra Mascaro, Anna
Letizia and Pavone, Francesco and Denker, Michael and
Paolucci, Pier Stanislao},
title = {{S}imulations approaching data: cortical slow waves in
inferred models of the whole hemisphere of mouse},
journal = {Communications biology},
volume = {6},
number = {1},
issn = {2399-3642},
address = {London},
publisher = {Springer Nature},
reportid = {FZJ-2023-01645},
pages = {266},
year = {2023},
abstract = {The development of novel techniques to record wide-field
brain activity enables estimation of data-driven models from
thousands of recording channels and hence across large
regions of cortex. These in turn improve our understanding
of the modulation of brain states and the richness of
traveling waves dynamics. Here, we infer data-driven models
from high-resolution in-vivo recordings of mouse brain
obtained from wide-field calcium imaging. We then assimilate
experimental and simulated data through the characterization
of the spatio-temporal features of cortical waves in
experimental recordings. Inference is built in two steps: an
inner loop that optimizes a mean-field model by likelihood
maximization, and an outer loop that optimizes a periodic
neuro-modulation via direct comparison of observables that
characterize cortical slow waves. The model reproduces most
of the features of the non-stationary and non-linear
dynamics present in the high-resolution in-vivo recordings
of the mouse brain. The proposed approach offers new methods
of characterizing and understanding cortical waves for
experimental and computational neuroscientists.},
cin = {INM-6 / IAS-6 / INM-10},
ddc = {570},
cid = {I:(DE-Juel1)INM-6-20090406 / I:(DE-Juel1)IAS-6-20130828 /
I:(DE-Juel1)INM-10-20170113},
pnm = {5231 - Neuroscientific Foundations (POF4-523) / 5235 -
Digitization of Neuroscience and User-Community Building
(POF4-523) / HBP SGA3 - Human Brain Project Specific Grant
Agreement 3 (945539) / HBP SGA2 - Human Brain Project
Specific Grant Agreement 2 (785907)},
pid = {G:(DE-HGF)POF4-5231 / G:(DE-HGF)POF4-5235 /
G:(EU-Grant)945539 / G:(EU-Grant)785907},
typ = {PUB:(DE-HGF)16},
pubmed = {36914748},
UT = {WOS:000948919700001},
doi = {10.1038/s42003-023-04580-0},
url = {https://juser.fz-juelich.de/record/1006405},
}