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001006583 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-01724
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001006583 020__ $$a978-3-95806-688-5
001006583 037__ $$aFZJ-2023-01724
001006583 1001_ $$0P:(DE-Juel1)169708$$aRama, Ramya$$b0$$eCorresponding author$$ufzj
001006583 245__ $$aMorphological and functional characterization of layer 5 neurons in rat medial prefrontal cortex, their synaptic microcircuitry and serotonin modulation$$f- 2023-07-18
001006583 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2023
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001006583 4900_ $$aSchriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies$$v267
001006583 502__ $$aDissertation, RWTH Aachen University, 2022$$bDissertation$$cRWTH Aachen University$$d2022
001006583 520__ $$aMedial prefrontal cortex (Cortex praefrontalis medialis, mPFC) is a part of the association cortex that serves to process and integrate synaptic inputs from sensory and motor cortical areas. The mPFC plays important roles in numerous cognitive processes, such as emotional processing, executive function, decision making, spatial orientation, long-term memory and impulse control. Compared to other cortical areas, the mPFC has a particularly high density of serotonergic axons which originate from the dorsal and medial raphe nuclei; they play a crucial role in regulating the development and function of the neocortex. For this reason, a basic knowledge of the role of serotonin (5-HT) and its receptors (5-HTRs) function in the mPFC in modulating cortical activity is crucial.
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