001006663 001__ 1006663
001006663 005__ 20240408211951.0
001006663 0247_ $$2doi$$a10.1111/ene.15818
001006663 0247_ $$2ISSN$$a1351-5101
001006663 0247_ $$2ISSN$$a1468-1331
001006663 0247_ $$2Handle$$a2128/34592
001006663 0247_ $$2pmid$$a37038631
001006663 0247_ $$2WOS$$aWOS:000973296600001
001006663 037__ $$aFZJ-2023-01782
001006663 082__ $$a610
001006663 1001_ $$00000-0001-5858-7762$$aOphey, Anja$$b0
001006663 245__ $$aVisuo‐spatial processing is linked to cortical glutamate dynamics in Parkinson's disease – a 7 Tesla functional MRS study
001006663 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2023
001006663 3367_ $$2DRIVER$$aarticle
001006663 3367_ $$2DataCite$$aOutput Types/Journal article
001006663 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1712566384_21291
001006663 3367_ $$2BibTeX$$aARTICLE
001006663 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001006663 3367_ $$00$$2EndNote$$aJournal Article
001006663 500__ $$a(DFG, German Research Foundation), Project-ID 431549029, SFB 1451.Eur J Neurol. 2023 Jul;30(7):2106-2111. Epub 2023 Apr 16.
001006663 520__ $$aBackground and purpose: Cognitive decline is a frequent and debilitating non-motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cognitive decline in patients with PD.Methods: Sixteen patients with PD (Unified Parkinson's Disease Rating Scale Part 3, OFF, 38.69 ± 17.25) and 10 age- and sex-matched healthy controls (HC) underwent 7-T functional magnetic resonance spectroscopy (MRS) utilizing a visual checkerboard stimulation. Glutamate metabolite levels during rest versus stimulation were compared. Furthermore, correlates of the functional MRS response with performance in visuo-cognitive tests were investigated.Results: No differences in static MRS between patients with PD and HC were detected, but a dynamic glutamate response was observed in functional MRS in HC upon visual stimulation, which was blunted in patients with PD (F1,22 = 7.13, p = 0.014; η2p= 0.245). A diminished glutamate response correlated with poorer performance in the Benton Judgment of Line Orientation test in PD (r = -0.57, p = 0.020).Conclusions: Our results indicate that functional MRS captures even subtle differences in neural processing linked to the behavioral performance, which would have been missed by conventional, static MRS. Functional MRS thus represents a promising tool for studying molecular alterations at high sensitivity. Its prognostic potential should be evaluated in longitudinal studies, prospectively contributing to earlier diagnosis and individual treatment decisions.Keywords: biomarker; cognitive decline; functional magnetic resonance spectroscopy; visuo-cognition.
001006663 536__ $$0G:(DE-HGF)POF4-5253$$a5253 - Neuroimaging (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001006663 536__ $$0G:(GEPRIS)431549029$$aDFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x1
001006663 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001006663 7001_ $$0P:(DE-Juel1)138244$$aFarrher, Ezequiel$$b1
001006663 7001_ $$0P:(DE-HGF)0$$aPagel, Nora$$b2
001006663 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline$$b3
001006663 7001_ $$0P:(DE-Juel1)161350$$aDoppler, Christopher E. J.$$b4
001006663 7001_ $$0P:(DE-Juel1)131794$$aShah, N. Jon$$b5
001006663 7001_ $$0P:(DE-HGF)0$$aKalbe, Elke$$b6
001006663 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7
001006663 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b8$$eCorresponding author
001006663 773__ $$0PERI:(DE-600)2020241-6$$a10.1111/ene.15818$$gp. ene.15818$$n7$$p2106-2111$$tEuropean journal of neurology$$v30$$x1351-5101$$y2023
001006663 8564_ $$uhttps://juser.fz-juelich.de/record/1006663/files/Euro%20J%20of%20Neurology%20-%202023%20-%20Ophey%20-%20Visuo%E2%80%90spatial%20processing%20is%20linked%20to%20cortical%20glutamate%20dynamics%20in%20Parkinson%20s.pdf$$yOpenAccess
001006663 909CO $$ooai:juser.fz-juelich.de:1006663$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001006663 9101_ $$0I:(DE-HGF)0$$60000-0001-5858-7762$$aExternal Institute$$b0$$kExtern
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138244$$aForschungszentrum Jülich$$b1$$kFZJ
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)184882$$aForschungszentrum Jülich$$b3$$kFZJ
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)161350$$aForschungszentrum Jülich$$b4$$kFZJ
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131794$$aForschungszentrum Jülich$$b5$$kFZJ
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b7$$kFZJ
001006663 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)179044$$aForschungszentrum Jülich$$b8$$kFZJ
001006663 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5253$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001006663 9141_ $$y2023
001006663 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-11
001006663 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-11
001006663 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
001006663 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2022-11-11$$wger
001006663 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-11
001006663 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001006663 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEUR J NEUROL : 2022$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-22
001006663 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bEUR J NEUROL : 2022$$d2023-10-22
001006663 9201_ $$0I:(DE-Juel1)VDB807$$kINB-4$$lNuklearchemie$$x0
001006663 9201_ $$0I:(DE-Juel1)INM-11-20170113$$kINM-11$$lJara-Institut Quantum Information$$x1
001006663 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x2
001006663 9201_ $$0I:(DE-82)080010_20140620$$kJARA-BRAIN$$lJARA-BRAIN$$x3
001006663 980__ $$ajournal
001006663 980__ $$aVDB
001006663 980__ $$aI:(DE-Juel1)VDB807
001006663 980__ $$aI:(DE-Juel1)INM-11-20170113
001006663 980__ $$aI:(DE-Juel1)INM-3-20090406
001006663 980__ $$aI:(DE-82)080010_20140620
001006663 980__ $$aUNRESTRICTED
001006663 9801_ $$aFullTexts