TY  - JOUR
AU  - Ophey, Anja
AU  - Farrher, Ezequiel
AU  - Pagel, Nora
AU  - Seger, Aline
AU  - Doppler, Christopher E. J.
AU  - Shah, N. Jon
AU  - Kalbe, Elke
AU  - Fink, Gereon R.
AU  - Sommerauer, Michael
TI  - Visuo‐spatial processing is linked to cortical glutamate dynamics in Parkinson's disease – a 7 Tesla functional MRS study
JO  - European journal of neurology
VL  - 30
IS  - 7
SN  - 1351-5101
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - FZJ-2023-01782
SP  - 2106-2111
PY  - 2023
N1  - (DFG, German Research Foundation), Project-ID 431549029, SFB 1451.Eur J Neurol. 2023 Jul;30(7):2106-2111. Epub 2023 Apr 16.
AB  - Background and purpose: Cognitive decline is a frequent and debilitating non-motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cognitive decline in patients with PD.Methods: Sixteen patients with PD (Unified Parkinson's Disease Rating Scale Part 3, OFF, 38.69 ± 17.25) and 10 age- and sex-matched healthy controls (HC) underwent 7-T functional magnetic resonance spectroscopy (MRS) utilizing a visual checkerboard stimulation. Glutamate metabolite levels during rest versus stimulation were compared. Furthermore, correlates of the functional MRS response with performance in visuo-cognitive tests were investigated.Results: No differences in static MRS between patients with PD and HC were detected, but a dynamic glutamate response was observed in functional MRS in HC upon visual stimulation, which was blunted in patients with PD (F1,22 = 7.13, p = 0.014; η2p= 0.245). A diminished glutamate response correlated with poorer performance in the Benton Judgment of Line Orientation test in PD (r = -0.57, p = 0.020).Conclusions: Our results indicate that functional MRS captures even subtle differences in neural processing linked to the behavioral performance, which would have been missed by conventional, static MRS. Functional MRS thus represents a promising tool for studying molecular alterations at high sensitivity. Its prognostic potential should be evaluated in longitudinal studies, prospectively contributing to earlier diagnosis and individual treatment decisions.Keywords: biomarker; cognitive decline; functional magnetic resonance spectroscopy; visuo-cognition.
LB  - PUB:(DE-HGF)16
C6  - 37038631
UR  - <Go to ISI:>//WOS:000973296600001
DO  - DOI:10.1111/ene.15818
UR  - https://juser.fz-juelich.de/record/1006663
ER  -