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@ARTICLE{Ophey:1006663,
      author       = {Ophey, Anja and Farrher, Ezequiel and Pagel, Nora and
                      Seger, Aline and Doppler, Christopher E. J. and Shah, N. Jon
                      and Kalbe, Elke and Fink, Gereon R. and Sommerauer, Michael},
      title        = {{V}isuo‐spatial processing is linked to cortical
                      glutamate dynamics in {P}arkinson's disease – a 7 {T}esla
                      functional {MRS} study},
      journal      = {European journal of neurology},
      volume       = {30},
      number       = {7},
      issn         = {1351-5101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2023-01782},
      pages        = {2106-2111},
      year         = {2023},
      note         = {(DFG, German Research Foundation), Project-ID 431549029,
                      SFB 1451.Eur J Neurol. 2023 Jul;30(7):2106-2111. Epub 2023
                      Apr 16.},
      abstract     = {Background and purpose: Cognitive decline is a frequent and
                      debilitating non-motor symptom for patients with Parkinson's
                      disease (PD). Metabolic alterations in the occipital cortex
                      during visual processing may serve as a biomarker for
                      cognitive decline in patients with PD.Methods: Sixteen
                      patients with PD (Unified Parkinson's Disease Rating Scale
                      Part 3, OFF, 38.69 ± 17.25) and 10 age- and sex-matched
                      healthy controls (HC) underwent 7-T functional magnetic
                      resonance spectroscopy (MRS) utilizing a visual checkerboard
                      stimulation. Glutamate metabolite levels during rest versus
                      stimulation were compared. Furthermore, correlates of the
                      functional MRS response with performance in visuo-cognitive
                      tests were investigated.Results: No differences in static
                      MRS between patients with PD and HC were detected, but a
                      dynamic glutamate response was observed in functional MRS in
                      HC upon visual stimulation, which was blunted in patients
                      with PD (F1,22 = 7.13, p = 0.014; η2p= 0.245). A diminished
                      glutamate response correlated with poorer performance in the
                      Benton Judgment of Line Orientation test in PD (r = -0.57, p
                      = 0.020).Conclusions: Our results indicate that functional
                      MRS captures even subtle differences in neural processing
                      linked to the behavioral performance, which would have been
                      missed by conventional, static MRS. Functional MRS thus
                      represents a promising tool for studying molecular
                      alterations at high sensitivity. Its prognostic potential
                      should be evaluated in longitudinal studies, prospectively
                      contributing to earlier diagnosis and individual treatment
                      decisions.Keywords: biomarker; cognitive decline; functional
                      magnetic resonance spectroscopy; visuo-cognition.},
      cin          = {INB-4 / INM-11 / INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB807 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)INM-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {5253 - Neuroimaging (POF4-525) / DFG project 431549029 -
                      SFB 1451: Schlüsselmechanismen normaler und
                      krankheitsbedingt gestörter motorischer Kontrolle
                      (431549029)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37038631},
      UT           = {WOS:000973296600001},
      doi          = {10.1111/ene.15818},
      url          = {https://juser.fz-juelich.de/record/1006663},
}