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001006765 1001_ $$0P:(DE-HGF)0$$aCash, Robin F. H.$$b0$$eCorresponding author
001006765 245__ $$aAltered brain activity in unipolar depression unveiled using connectomics
001006765 260__ $$aLondon$$bNature Publishing Group UK$$c2023
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001006765 520__ $$aOver 20 years of neuroimaging experiments into aberrant task-based brain activity in unipolar depression have failed to reliably delineate a convergent set of anatomical regions. Here we examined whether study-derived coordinates might delineate a dysfunctional brain network in unipolar depression rather than isolated neuroanatomical foci, utilizing data from 57 studies with 99 individual neuroimaging task-based experiments, testing either emotional or cognitive processing (n = 1,058). We further assessed clinical relevance by computing optimal network-based personalized targets in 26 individuals who previously received transcranial magnetic stimulation for unipolar depression. Although coordinates were neuroanatomically heterogeneous, they localized to highly robust distributed brain networks. Importantly, these networks closely recapitulated clinically meaningful and independently derived models of depression circuitry, quantified by spatial correlation (P < 0.00002). Therapeutic outcome of transcranial magnetic stimulation was dependent on how effectively this circuit was targeted (P = 0.018). These findings indicate that neuroimaging findings in depression, which previously appeared irreconcilable, localize to highly robust and clinically meaningful distributed brain networks.
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001006765 7001_ $$0P:(DE-Juel1)131699$$aMüller, Veronika I.$$b1$$ufzj
001006765 7001_ $$0P:(DE-HGF)0$$aFitzgerald, Paul B.$$b2
001006765 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b3$$ufzj
001006765 7001_ $$0P:(DE-HGF)0$$aZalesky, Andrew$$b4
001006765 773__ $$0PERI:(DE-600)3123130-5$$a10.1038/s44220-023-00038-8$$gVol. 1, no. 3, p. 174 - 185$$n3$$p174 - 185$$tNature Mental Health$$v1$$x2731-6076$$y2023
001006765 8564_ $$uhttps://juser.fz-juelich.de/record/1006765/files/s44220-023-00038-8.pdf
001006765 8564_ $$uhttps://juser.fz-juelich.de/record/1006765/files/Altered%20brain%20ms_clean_v4.docx$$yPublished on 2023-03-22. Available in OpenAccess from 2023-09-22.
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001006765 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Melbourne Neuropsychiatry Centre, The University of Melbourne$$b0
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001006765 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a The Australian National University, Canberra, Australian Capital Territory$$b2
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001006765 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a The University of Melbourne$$b4
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001006765 9141_ $$y2023
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