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| Hauptseite > Publikationsdatenbank > Technical, conceptual and practical considerations on neuroimaging-based prediction of cognitive phenotypes |
| Hauptseite > Publikationsdatenbank > Technical, conceptual and practical considerations on neuroimaging-based prediction of cognitive phenotypes |
| Talk (non-conference) (Invited) | FZJ-2023-01903 |
2023
Abstract: The long predominant paradigm in neuroimaging has been to compare (mean) local volumeor activity between groups, or to correlate these to behavioral phenotypes. Over the lastdecades, the increasing availability of large cohorts and tools for multivariate statisticallearning, allowing the prediction of individual cognitive or clinical phenotypes in newsubjects, started a revolution in imaging neuroscience. While the field has enjoyed a lot ofenthusiasm recently, with medical and non-medical applications on the horizon, the roadtowards translation and re-life applications may be considerably more challenging thanoften acknowledged. Following a short overview on the motivation and perspectives, themajor part of my talk will be focus on several critical yet often underappreciated challengesfor such endeavors. These include on the one hand technical and biological aspects thatmay undermine the validity of prediction results, in particular due to the inherent low-dimensional structure of biological variability. On the other hand, ethical, legal and societalaspects will ultimately will shape practical adaptation but need stronger consideration in thedevelopment of new pipelines if these are to move beyond proof-of-concept work.
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