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@ARTICLE{Unger:1006996,
      author       = {Unger, Nina and Eickhoff, Simon and Camilleri, Julia and
                      Dickscheid, Timo and Mohlberg, Hartmut and Bludau, Sebastian
                      and Caspers, Svenja and Amunts, Katrin},
      title        = {{C}ytoarchitectonic mapping of the human frontal operculum
                      – new correlates for a variety of brain functions},
      journal      = {Frontiers in human neuroscience},
      volume       = {17},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2023-01935},
      pages        = {},
      year         = {2023},
      abstract     = {The human frontal operculum (FOp) is a brain region that
                      covers parts of the ventral frontal cortex next to the
                      insula. Functional imaging studies showed activations in
                      this region in tasks related to language, somatosensory, and
                      cognitive functions. While the precise cytoarchitectonic
                      areas that correlate to these processes have not yet been
                      revealed, earlier receptorarchitectonic analysis resulted in
                      a detailed parcellation of the FOp.We complemented this
                      analysis by a cytoarchitectonic study of a sample of ten
                      postmortem brains and mapped the posterior FOp in serial,
                      cell-body stained histological sections using image analysis
                      and multivariate statistics. Three new areas were
                      identified: Op5 represents the most posterior area, followed
                      by Op6 and the most anterior region Op7. Areas Op5-Op7
                      approach the insula, up to the circular sulcus. Area 44 of
                      Broca’s region, the most ventral part of premotor area 6,
                      and parts of the parietal operculum are dorso-laterally
                      adjacent to Op5-Op7. The areas did not show any
                      interhemispheric or sex differences. Three-dimensional
                      probability maps and a maximum probability map were
                      generated in stereotaxic space, and then used, in a first
                      proof-of-concept-study, for functional decoding and analysis
                      of structural and functional connectivity.Functional
                      decoding revealed different profiles of
                      cytoarchitectonically identified Op5-Op7. While left Op6 was
                      active in music cognition, right Op5 was involved in
                      chewing/swallowing and sexual processing. Both areas showed
                      activation during the exercise of isometric force in
                      muscles. An involvement in the coordination of
                      flexion/extension could be shown for the right Op6.
                      Meta-analytic connectivity modeling revealed various
                      functional connections of the FOp areas within motor and
                      somatosensory networks, with the most evident connection
                      with the music/language network for Op6 left. The new
                      cytoarchitectonic maps are part of Julich Brain, and
                      publicly available to serve as a basis for future analyses
                      of structural-functional relationships in this region.},
      cin          = {INM-1 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37448625},
      UT           = {WOS:001023793000001},
      doi          = {10.3389/fnhum.2023.1087026},
      url          = {https://juser.fz-juelich.de/record/1006996},
}