%0 Journal Article
%A Sarter, Mona
%A Niether, Doreen
%A Wiegand, Simone
%A Fitter, Joerg
%A Stadler, Andreas M.
%T Complementary approaches to obtaining thermodynamic parameters from protein ligand systems-challenges and opportunities
%J The European physical journal / Web of Conferences
%V 272
%@ 2100-014X
%C Les Ulis
%I EDP Sciences
%M FZJ-2023-02080
%P 01016 -
%D 2022
%X Protein ligand interactions play an important role in biology. Increasingly the aim is to understandand influence protein ligand binding. The binding process is heavily influenced by its thermodynamicparameters. In order to understand how the whole system thermodynamics work it is important to characterisethe individual contribution of each of the systems components. While the change in conformational entropyof the protein can be determined using QENS complementary methods are necessary in order to characteriseall components. This paper will describe the challenges that can occur when combining the different methods,as well as how they can be overcome.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1051/epjconf/202227201016
%U https://juser.fz-juelich.de/record/1007490