guest ::
| Home > Publications database > Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity > print |
| Home > Publications database > Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity > print |
| 001 | 1007674 | ||
| 005 | 20240129202807.0 | ||
| 024 | 7 | _ | |a 10.1172/JCI162253 |2 doi |
| 024 | 7 | _ | |a 0021-9738 |2 ISSN |
| 024 | 7 | _ | |a 1558-8238 |2 ISSN |
| 024 | 7 | _ | |a 2128/34466 |2 Handle |
| 024 | 7 | _ | |a 36995772 |2 pmid |
| 024 | 7 | _ | |a WOS:000998153000004 |2 WOS |
| 037 | _ | _ | |a FZJ-2023-02157 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Stokowska, Anna |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity |
| 260 | _ | _ | |a Ann Arbor, Mich. |c 2023 |b ASCJ |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1706531815_11227 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome. The complement C3a receptor (C3aR) is a regulator of inflammation with roles in neurodevelopment, neural plasticity, and neurodegeneration. Using mice lacking C3aR (C3aR–/–) and mice overexpressing C3a in the brain, we uncovered 2 opposing effects of C3aR signaling on functional recovery after ischemic stroke: inhibition in the acute phase and facilitation in the later phase. Peri-infarct astrocyte reactivity was increased and density of microglia reduced in C3aR–/– mice; C3a overexpression led to the opposite effects. Pharmacological treatment of wild-type mice with intranasal C3a starting 7 days after stroke accelerated recovery of motor function and attenuated astrocyte reactivity without enhancing microgliosis. C3a treatment stimulated global white matter reorganization, increased peri-infarct structural connectivity, and upregulated Igf1 and Thbs4 in the peri-infarct cortex. Thus, C3a treatment from day 7 after stroke exerts positive effects on astrocytes and neuronal connectivity while avoiding the deleterious consequences of C3aR signaling during the acute phase. Intranasal administration of C3aR agonists within a convenient time window holds translational promise to improve outcome after ischemic stroke. |
| 536 | _ | _ | |a 5251 - Multilevel Brain Organization and Variability (POF4-525) |0 G:(DE-HGF)POF4-5251 |c POF4-525 |f POF IV |x 0 |
| 536 | _ | _ | |a DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) |0 G:(GEPRIS)431549029 |c 431549029 |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Aswendt, Markus |0 P:(DE-Juel1)196051 |b 1 |
| 700 | 1 | _ | |a Zucha, Daniel |0 0000-0002-2469-1315 |b 2 |
| 700 | 1 | _ | |a Lohmann, Stephanie |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Wieters, Frederique |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Morán Suarez, Javier |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Atkins, Alison L. |b 6 |
| 700 | 1 | _ | |a Li, YiXian |b 7 |
| 700 | 1 | _ | |a Miteva, Maria |b 8 |
| 700 | 1 | _ | |a Lewin, Julia |b 9 |
| 700 | 1 | _ | |a Wiedermann, Dirk |b 10 |
| 700 | 1 | _ | |a Diedenhofen, Michael |b 11 |
| 700 | 1 | _ | |a Torinsson Naluai, Åsa |b 12 |
| 700 | 1 | _ | |a Abaffy, Pavel |0 0000-0002-7571-8880 |b 13 |
| 700 | 1 | _ | |a Valihrach, Lukas |0 0000-0002-6704-4337 |b 14 |
| 700 | 1 | _ | |a Kubista, Mikael |b 15 |
| 700 | 1 | _ | |a Hoehn, Mathias |0 P:(DE-Juel1)176651 |b 16 |
| 700 | 1 | _ | |a Pekny, Milos |0 P:(DE-HGF)0 |b 17 |
| 700 | 1 | _ | |a Pekna, Marcela |0 0000-0003-2734-8237 |b 18 |e Corresponding author |
| 773 | _ | _ | |a 10.1172/JCI162253 |g Vol. 133, no. 10, p. e162253 |0 PERI:(DE-600)2018375-6 |n 10 |p e162253 |t The journal of clinical investigation |v 133 |y 2023 |x 0021-9738 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1007674/files/JCI162253.v2.pdf |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:1007674 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)196051 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 16 |6 P:(DE-Juel1)176651 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-525 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Decoding Brain Organization and Dysfunction |9 G:(DE-HGF)POF4-5251 |x 0 |
| 914 | 1 | _ | |y 2023 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2022-11-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2022-11-30 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2022-11-30 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2022-11-30 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2022-11-30 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2023-02-14T21:03:14Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2023-02-14T21:03:14Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Peer review |d 2023-02-14T21:03:14Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-10-22 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J CLIN INVEST : 2022 |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-10-22 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-10-22 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-10-22 |
| 915 | _ | _ | |a IF >= 15 |0 StatID:(DE-HGF)9915 |2 StatID |b J CLIN INVEST : 2022 |d 2023-10-22 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-3-20090406 |k INM-3 |l Kognitive Neurowissenschaften |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-3-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|