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@ARTICLE{Ramkiran:1007800,
      author       = {Ramkiran, Shukti and Veselinović, Tanja and Dammers,
                      Jürgen and Gaebler, Arnim Johannes and Rajkumar,
                      Ravichandran and Shah, N. Jon and Neuner, Irene},
      title        = {{H}ow brain networks tic: {P}redicting tic severity through
                      rs‐f{MRI} dynamics in {T}ourette syndrome},
      journal      = {Human brain mapping},
      volume       = {44},
      number       = {11},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2023-02195},
      pages        = {4225-4238},
      year         = {2023},
      abstract     = {Tourette syndrome (TS) is a neuropsychiatric disorder
                      characterized by motor and phonic tics, which several
                      different theories, such as basal ganglia-thalamo-cortical
                      loop dysfunction and amygdala hypersensitivity, have sought
                      to explain. Previous research has shown dynamic changes in
                      the brain prior to tic onset leading to tics, and this study
                      aims to investigate the contribution of network dynamics to
                      them. For this, we have employed three methods of functional
                      connectivity to resting-state fMRI data – namely the
                      static, the sliding window dynamic and the ICA based
                      estimated dynamic; followed by an examination of the static
                      and dynamic network topological properties. A leave-one-out
                      (LOO-) validated regression model with LASSO regularization
                      was used to identify the key predictors. The relevant
                      predictors pointed to dysfunction of the primary motor
                      cortex, the prefrontal-basal ganglia loop and
                      amygdala-mediated visual social processing network. This is
                      in line with a recently proposed social decision-making
                      dysfunction hypothesis, opening new horizons in
                      understanding tic pathophysiology.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37232486},
      UT           = {WOS:000994935800001},
      doi          = {10.1002/hbm.26341},
      url          = {https://juser.fz-juelich.de/record/1007800},
}