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@ARTICLE{Drakatos:1007827,
      author       = {Drakatos, Panagis and O’Regan, David and Liao, Yingqi and
                      Panayiotou, Constantinos and Higgins, Sean and Kabiljo,
                      Renata and Benson, Joshua and Pool, Norman and Tahmasian,
                      Masoud and Romigi, Andrea and Nesbitt, Alexander and Stokes,
                      Paul R. A. and Kumari, Veena and Young, Allan H. and
                      Rosenzweig, Ivana},
      title        = {{P}rofile of sleep disturbances in patients with recurrent
                      depressive disorder or bipolar affective disorder in a
                      tertiary sleep disorders service},
      journal      = {Scientific reports},
      volume       = {13},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2023-02212},
      pages        = {8785},
      year         = {2023},
      abstract     = {Bidirectional relationship between sleep disturbances and
                      affective disorders is increasingly recognised, but its
                      underlying mechanisms are far from clear, and there is a
                      scarcity of studies that report on sleep disturbances in
                      recurrent depressive disorder (RDD) and bipolar affective
                      disorder (BPAD). To address this, we conducted a
                      retrospective study of polysomnographic and clinical records
                      of patients presenting to a tertiary sleep disorders clinic
                      with affective disorders. Sixty-three BPAD patients (32
                      female; mean age ± S.D.: 41.8 ± 12.4 years) and
                      126 age- and gender-matched RDD patients (62 female;
                      41.5 ± 12.8) were studied. Whilst no significant
                      differences were observed in sleep macrostructure parameters
                      between BPAD and RDD patients, major differences were
                      observed in comorbid sleep and physical disorders, both of
                      which were higher in BPAD patients. Two most prevalent sleep
                      disorders, namely obstructive sleep apnoea (OSA) (BPAD
                      $50.8.0\%$ vs RDD $29.3\%,$ P = 0.006) and insomnia
                      (BPAD $34.9\%$ vs RDD $15.0\%,$ P = 0.005) were found to
                      be strongly linked with BPAD. In summary, in our tertiary
                      sleep clinic cohort, no overt differences in the sleep
                      macrostructure between BPAD and RDD patients were
                      demonstrated. However, OSA and insomnia, two most prevalent
                      sleep disorders, were found significantly more prevalent in
                      patients with BPAD, by comparison to RDD patients. Also,
                      BPAD patients presented with significantly more severe OSA,
                      and with higher overall physical co-morbidity. Thus, our
                      findings suggest an unmet/hidden need for earlier diagnosis
                      of those with BPAD.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37258713},
      UT           = {WOS:001001303600011},
      doi          = {10.1038/s41598-023-36083-7},
      url          = {https://juser.fz-juelich.de/record/1007827},
}