TY  - THES
AU  - Ramp, Paul
TI  - The complex inositol metabolism of Corynebacterium glutamicum and its application for the production of rare inositols
VL  - 269
PB  - Univ. Düsseldorf
VL  - Dissertation
CY  - Jülich
M1  - FZJ-2023-02247
SN  - 978-3-95806-699-1
T2  - Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies
SP  - VI, 161
PY  - 2023
N1  - Sperrvermerk!!
N1  - Dissertation, Univ. Düsseldorf, 2023
AB  - Inositols (cyclohexanehexols) comprise nine isomeric cyclic sugar alcohols, several of which occur in all domains of life with various functions. The most abundant isomer is myo-inositol (MI). Its rare isomers, scyllo- (SI) and D-chiro-inositol (DCI) are promising drug candidates fortreating Alzheimer’s disease, diabetes type 2 and polycystic ovary syndrome. Therefore, cost efficient processes for the production of these compounds are desirable. Many bacteria can utilize inositols as carbon and energy source via a specific pathway involving inositoldehydrogenases (IDHs) as the first step of catabolism, followed by the actions of inosose isomerases. The microbial cell factory Corynebacterium glutamicum can grow on MI as sole carbon source and possesses many uncharacterized genes that are annotated to contribute toinositol degradation. It also has the innate ability to synthesize MI from glucose-6-phosphate. This thesis aimed to elucidate the function of the undescribed genes for inositol metabolism and exploit the potential of C. glutamicum to be engineered as a suitable host for the biotechnological production of SI and DCI.
LB  - PUB:(DE-HGF)3 ; PUB:(DE-HGF)11
DO  - DOI:10.34734/FZJ-2023-02247
UR  - https://juser.fz-juelich.de/record/1008201
ER  -