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@PHDTHESIS{Ramp:1008201,
      author       = {Ramp, Paul},
      title        = {{T}he complex inositol metabolism of {C}orynebacterium
                      glutamicum and its application for the production of rare
                      inositols},
      volume       = {269},
      school       = {Univ. Düsseldorf},
      type         = {Dissertation},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2023-02247},
      isbn         = {978-3-95806-699-1},
      series       = {Schriften des Forschungszentrums Jülich Reihe
                      Schlüsseltechnologien / Key Technologies},
      pages        = {VI, 161},
      year         = {2023},
      note         = {Sperrvermerk!!; Dissertation, Univ. Düsseldorf, 2023},
      abstract     = {Inositols (cyclohexanehexols) comprise nine isomeric cyclic
                      sugar alcohols, several of which occur in all domains of
                      life with various functions. The most abundant isomer is
                      myo-inositol (MI). Its rare isomers, scyllo- (SI) and
                      D-chiro-inositol (DCI) are promising drug candidates
                      fortreating Alzheimer’s disease, diabetes type 2 and
                      polycystic ovary syndrome. Therefore, cost efficient
                      processes for the production of these compounds are
                      desirable. Many bacteria can utilize inositols as carbon and
                      energy source via a specific pathway involving
                      inositoldehydrogenases (IDHs) as the first step of
                      catabolism, followed by the actions of inosose isomerases.
                      The microbial cell factory Corynebacterium glutamicum can
                      grow on MI as sole carbon source and possesses many
                      uncharacterized genes that are annotated to contribute
                      toinositol degradation. It also has the innate ability to
                      synthesize MI from glucose-6-phosphate. This thesis aimed to
                      elucidate the function of the undescribed genes for inositol
                      metabolism and exploit the potential of C. glutamicum to be
                      engineered as a suitable host for the biotechnological
                      production of SI and DCI.},
      cin          = {IBG-1},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-20230718091317719-1329333-8},
      doi          = {10.34734/FZJ-2023-02247},
      url          = {https://juser.fz-juelich.de/record/1008201},
}