% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Gogishvili:1008222,
      author       = {Gogishvili, Ana and Farrher, Ezequiel and Doppler,
                      Christopher E. J. and Seger, Aline and Sommerauer, Michael
                      and Shah, N. Jon},
      title        = {{Q}uantification of the neurochemical profile of the human
                      putamen using {STEAM} {MRS} in a cohort of elderly subjects
                      at 3 {T} and 7 {T}: {R}uminations on the correction strategy
                      for the tissue voxel composition},
      journal      = {PLOS ONE},
      volume       = {18},
      number       = {6},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {FZJ-2023-02262},
      pages        = {e0286633 -},
      year         = {2023},
      note         = {DFG, FI 773/15-1},
      abstract     = {The aim of this work is to quantify the metabolic profile
                      of the human putamen in vivo in a cohort of elderly subjects
                      using single-voxel proton magnetic resonance spectroscopy.
                      To obtain metabolite concentrations specific to the putamen,
                      we investigated a correction method previously proposed to
                      account for the tissue composition of the volume of
                      interest. We compared the method with the conventional
                      approach, which a priori assumes equal metabolite
                      concentrations in GM and WM. Finally, we compared the
                      concentrations acquired at 3 Tesla (T) and 7 T MRI scanners.
                      Spectra were acquired from 15 subjects (age: 67.7 ± 8.3
                      years) at 3 T and 7 T, using an ultra-short echo time,
                      stimulated echo acquisition mode sequence. To robustly
                      estimate the WM-to-GM metabolite concentration ratio, five
                      additional subjects were measured for whom the MRS voxel was
                      deliberately shifted from the putamen in order to increase
                      the covered amount of surrounding WM. The concentration and
                      WM-to-GM concentration ratio for 16 metabolites were
                      reliably estimated. These ratios ranged from ~0.3 for
                      γ-aminobutyric acid to ~4 for N-acetylaspartylglutamate.
                      The investigated correction method led to significant
                      changes in concentrations compared to the conventional
                      method, provided that the ratio significantly differed from
                      unity. Finally, we demonstrated that differences in tissue
                      voxel composition cannot fully account for the observed
                      concentration difference between field strengths. We provide
                      not only a fully comprehensive quantification of the
                      neurochemical profile of the putamen in elderly subjects,
                      but also a quantification of the WM-to-GM concentration
                      ratio. This knowledge may serve as a basis for future
                      studies with varying tissue voxel composition, either due to
                      tissue atrophy, inconsistent voxel positioning or simply
                      when pooling data from different voxel locations.},
      cin          = {INM-3 / INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-11-20170113 / $I:(DE-82)080010_20140620$},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37267283},
      UT           = {WOS:001000808800101},
      doi          = {10.1371/journal.pone.0286633},
      url          = {https://juser.fz-juelich.de/record/1008222},
}