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@ARTICLE{JankovicRapan:1008349,
author = {Jankovic-Rapan, Lucija and Froudist-Walsh, Sean and Niu,
Meiqi and Ting, Xu and Zhao, Ling and Funck, Thomas and
Wang, Xiao-Jing and Amunts, Katrin and Palomero-Gallagher,
Nicola},
title = {{C}ytoarchitectonic, receptor distribution and functional
connectivity analyses of the macaque frontal lobe},
journal = {eLife},
volume = {12},
issn = {2050-084X},
address = {Cambridge},
publisher = {eLife Sciences Publications},
reportid = {FZJ-2023-02295},
pages = {e82850},
year = {2023},
abstract = {Based on quantitative cyto- and receptor architectonic
analyses, we identified 35 prefrontal areas, including novel
subdivisions of Walker’s areas 10, 9, 8B, and 46.
Statistical analysis of receptor densities revealed regional
differences in lateral and ventrolateral prefrontal cortex.
Indeed, structural and functional organization of
subdivisions encompassing areas 46 and 12 demonstrated
significant differences in the interareal levels of α2
receptors. Furthermore, multivariate analysis included
receptor fingerprints of previously identified 16 motor
areas in the same macaque brains and revealed 5 clusters
encompassing frontal lobe areas. We used the MRI datasets
from the non-human primate data sharing consortium PRIME-DE
to perform functional connectivity analyses using the
resulting frontal maps as seed regions. In general,
rostrally located frontal areas were characterized by bigger
fingerprints, that is, higher receptor densities, and
stronger regional interconnections. Whereas more caudal
areas had smaller fingerprints, but showed a widespread
connectivity pattern with distant cortical regions. Taken
together, this study provides a comprehensive insight into
the molecular structure underlying the functional
organization of the cortex and, thus, reconcile the
discrepancies between the structural and functional
hierarchical organization of the primate frontal lobe.
Finally, our data are publicly available via the EBRAINS and
BALSA repositories for the entire scientific community.},
cin = {INM-1},
ddc = {600},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
Agreement 3 (945539) / HIBALL - Helmholtz International
BigBrain Analytics and Learning Laboratory (HIBALL)
(InterLabs-0015) / 3D-MMA - 3D-MMA-Gradienten der Verteilung
multipler Transmitterrezeptoren in der Hirnrinde als
Grundlage verteilter kognitiver, sensorischer und
motorischer Funktionen (BMBF-01GQ1902)},
pid = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539 /
G:(DE-HGF)InterLabs-0015 / G:(DE-Juel-1)BMBF-01GQ1902},
typ = {PUB:(DE-HGF)16},
pubmed = {37578332},
UT = {WOS:001077772400001},
doi = {10.7554/eLife.82850},
url = {https://juser.fz-juelich.de/record/1008349},
}