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001008453 1001_ $$0P:(DE-Juel1)176599$$aBabaki, Mehrnaz$$b0$$ufzj
001008453 245__ $$aCompetition between deformation and free volume quantified by 3D image analysis of red blood cell
001008453 260__ $$aBethesda, Md.$$bSoc.$$c2023
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001008453 520__ $$aCells in living organisms are subjected to mechanical strains caused by external forces like overcrowding, resulting in strong deformations that affect cell function. We study the interplay between deformation and crowding of red blood cells (RBCs) in dispersions of nonabsorbing rod-like viruses. We identify a sequence of configurational transitions of RBC doublets, including configurations that can only be induced by long-ranged attraction: highly fluctuating T-shaped and face-to-face configurations at low, and doublets approaching a complete spherical configuration at high, rod concentrations. Complementary simulations are used to explore different energy contributions to deformation as well as the stability of RBC doublet configurations. Our advanced analysis of 3D reconstructed confocal images of RBC doublets quantifies the depletion interaction and the resulting deformation energy. Thus, we introduce a noninvasive, high-throughput platform that is generally applicable to investigate the mechanical response of biological cells to external forces and characterize their mechanical properties.
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001008453 7001_ $$0P:(DE-Juel1)140336$$aFedosov, Dmitry A.$$b1$$ufzj
001008453 7001_ $$0P:(DE-Juel1)177939$$aGholivand, Amirreza$$b2$$ufzj
001008453 7001_ $$0P:(DE-HGF)0$$aOpdam, Joeri$$b3
001008453 7001_ $$0P:(DE-HGF)0$$aTuinier, Remco$$b4
001008453 7001_ $$0P:(DE-Juel1)130797$$aLettinga, Minne Paul$$b5$$eCorresponding author
001008453 773__ $$0PERI:(DE-600)1477214-0$$a10.1016/j.bpj.2023.03.030$$gVol. 122, no. 9, p. 1646 - 1658$$n9$$p1646 - 1658$$tBiophysical journal$$v122$$x0006-3495$$y2023
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