%0 Journal Article
%A Strelow, Joshua N.
%A Dembek, Till A.
%A Baldermann, Juan C.
%A Andrade, Pablo
%A Fink, Gereon R.
%A Visser-Vandewalle, Veerle
%A Barbe, Michael T.
%T Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
%J Parkinsonism & related disorders
%V 112
%@ 1353-8020
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2023-02378
%P 105478 -
%D 2023
%X AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37331065
%U <Go to ISI:>//WOS:001025640500001
%R 10.1016/j.parkreldis.2023.105478
%U https://juser.fz-juelich.de/record/1008541