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001008541 1001_ $$0P:(DE-HGF)0$$aStrelow, Joshua N.$$b0$$eCorresponding author
001008541 245__ $$aLow beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
001008541 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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001008541 520__ $$aAbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).
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001008541 7001_ $$0P:(DE-HGF)0$$aDembek, Till A.$$b1
001008541 7001_ $$0P:(DE-HGF)0$$aBaldermann, Juan C.$$b2
001008541 7001_ $$0P:(DE-HGF)0$$aAndrade, Pablo$$b3
001008541 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b4
001008541 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b5
001008541 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b6
001008541 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2023.105478$$gVol. 112, p. 105478 -$$p105478 -$$tParkinsonism & related disorders$$v112$$x1353-8020$$y2023
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