TY  - JOUR
AU  - Strelow, Joshua N.
AU  - Dembek, Till A.
AU  - Baldermann, Juan C.
AU  - Andrade, Pablo
AU  - Fink, Gereon R.
AU  - Visser-Vandewalle, Veerle
AU  - Barbe, Michael T.
TI  - Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
JO  - Parkinsonism & related disorders
VL  - 112
SN  - 1353-8020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2023-02378
SP  - 105478 -
PY  - 2023
AB  - AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).
LB  - PUB:(DE-HGF)16
C6  - 37331065
UR  - <Go to ISI:>//WOS:001025640500001
DO  - DOI:10.1016/j.parkreldis.2023.105478
UR  - https://juser.fz-juelich.de/record/1008541
ER  -