001008542 001__ 1008542
001008542 005__ 20240116084316.0
001008542 0247_ $$2doi$$a10.1016/j.parkreldis.2023.105487
001008542 0247_ $$2ISSN$$a1353-8020
001008542 0247_ $$2ISSN$$a1873-5126
001008542 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-02379
001008542 0247_ $$2pmid$$a37329726
001008542 0247_ $$2WOS$$aWOS:001024691600001
001008542 037__ $$aFZJ-2023-02379
001008542 082__ $$a610
001008542 1001_ $$0P:(DE-HGF)0$$aThies, Tabea$$b0$$eCorresponding author
001008542 245__ $$aCompensatory articulatory mechanisms preserve intelligibility in prodromal Parkinson's disease
001008542 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
001008542 3367_ $$2DRIVER$$aarticle
001008542 3367_ $$2DataCite$$aOutput Types/Journal article
001008542 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1701839853_23799
001008542 3367_ $$2BibTeX$$aARTICLE
001008542 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001008542 3367_ $$00$$2EndNote$$aJournal Article
001008542 520__ $$aAbstractIntroduction: Dysarthria is highly prevalent in patients with Parkinson's disease (PD) and speech changes have already been detected in patients with prodromal PD on the acoustic level. However, the present study directly tracks underlying articulatory movements with electromagnetic articulography to investigate early speech alterations on the kinematic level in isolated REM sleep behavior disorder (iRBD) and compares them to PD and control speakers.Methods: Kinematic data of 23 control speakers, 22 speakers with iRBD, and 23 speakers with PD were collected. Amplitude, duration, and average speed of lower lip, tongue tip, and tongue body movements were analyzed. Naive listeners rated the intelligibility of all speakers.Results: Patients with iRBD produced tongue tip and tongue body movements that were larger in amplitude and longer in duration compared to control speakers, while remaining intelligible. Compared to patients with iRBD, patients with PD had smaller, longer and slower tongue tip and lower lip movements, accompanied by lower intelligibility. Thus, the data indicate that the lingual system is already affected in prodromal PD. Furthermore, lower lip and especially tongue tip movements slow down and speech intelligibility decreases if motor impairment is more pronounced.Conclusion: Patients with iRBD adjust articulatory patterns to counteract incipient motor detriment on speech to maintain their intelligibility level.
001008542 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001008542 536__ $$0G:(GEPRIS)431549029$$aDFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x1
001008542 536__ $$0G:(GEPRIS)491111487$$aDFG project 491111487 - Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487)$$c491111487$$x2
001008542 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001008542 7001_ $$00000-0002-6217-3121$$aMücke, Doris$$b1
001008542 7001_ $$00009-0004-0319-4901$$aGeerts, Nuria$$b2
001008542 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline$$b3
001008542 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b4
001008542 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b5
001008542 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b6
001008542 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2023.105487$$gVol. 112, p. 105487 -$$p105487 -$$tParkinsonism & related disorders$$v112$$x1353-8020$$y2023
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/PDF-2.pdf$$yRestricted
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/post-print.docx.pdf$$yOpenAccess
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/PDF-2.gif?subformat=icon$$xicon$$yRestricted
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/PDF-2.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/PDF-2.jpg?subformat=icon-180$$xicon-180$$yRestricted
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/PDF-2.jpg?subformat=icon-640$$xicon-640$$yRestricted
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/post-print.gif?subformat=icon$$xicon$$yOpenAccess
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/post-print.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/post-print.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
001008542 8564_ $$uhttps://juser.fz-juelich.de/record/1008542/files/post-print.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
001008542 909CO $$ooai:juser.fz-juelich.de:1008542$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001008542 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)184882$$aForschungszentrum Jülich$$b3$$kFZJ
001008542 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b4$$kFZJ
001008542 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)179044$$aForschungszentrum Jülich$$b6$$kFZJ
001008542 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001008542 9141_ $$y2023
001008542 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-12
001008542 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001008542 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-12
001008542 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPARKINSONISM RELAT D : 2022$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-24
001008542 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-10-24
001008542 920__ $$lyes
001008542 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
001008542 980__ $$ajournal
001008542 980__ $$aVDB
001008542 980__ $$aUNRESTRICTED
001008542 980__ $$aI:(DE-Juel1)INM-3-20090406
001008542 9801_ $$aFullTexts