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@ARTICLE{Thies:1008542,
      author       = {Thies, Tabea and Mücke, Doris and Geerts, Nuria and Seger,
                      Aline and Fink, Gereon Rudolf and Barbe, Michael and
                      Sommerauer, Michael},
      title        = {{C}ompensatory articulatory mechanisms preserve
                      intelligibility in prodromal {P}arkinson's disease},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {112},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2023-02379},
      pages        = {105487 -},
      year         = {2023},
      abstract     = {AbstractIntroduction: Dysarthria is highly prevalent in
                      patients with Parkinson's disease (PD) and speech changes
                      have already been detected in patients with prodromal PD on
                      the acoustic level. However, the present study directly
                      tracks underlying articulatory movements with
                      electromagnetic articulography to investigate early speech
                      alterations on the kinematic level in isolated REM sleep
                      behavior disorder (iRBD) and compares them to PD and control
                      speakers.Methods: Kinematic data of 23 control speakers, 22
                      speakers with iRBD, and 23 speakers with PD were collected.
                      Amplitude, duration, and average speed of lower lip, tongue
                      tip, and tongue body movements were analyzed. Naive
                      listeners rated the intelligibility of all speakers.Results:
                      Patients with iRBD produced tongue tip and tongue body
                      movements that were larger in amplitude and longer in
                      duration compared to control speakers, while remaining
                      intelligible. Compared to patients with iRBD, patients with
                      PD had smaller, longer and slower tongue tip and lower lip
                      movements, accompanied by lower intelligibility. Thus, the
                      data indicate that the lingual system is already affected in
                      prodromal PD. Furthermore, lower lip and especially tongue
                      tip movements slow down and speech intelligibility decreases
                      if motor impairment is more pronounced.Conclusion: Patients
                      with iRBD adjust articulatory patterns to counteract
                      incipient motor detriment on speech to maintain their
                      intelligibility level.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project 431549029 - SFB 1451: Schlüsselmechanismen normaler
                      und krankheitsbedingt gestörter motorischer Kontrolle
                      (431549029) / DFG project 491111487 -
                      Open-Access-Publikationskosten / 2022 - 2024 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029 /
                      G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37329726},
      UT           = {WOS:001024691600001},
      doi          = {10.1016/j.parkreldis.2023.105487},
      url          = {https://juser.fz-juelich.de/record/1008542},
}