TY  - JOUR
AU  - Froudist-Walsh, Sean
AU  - Xu, Ting
AU  - Niu, Meiqi
AU  - Rapan, Lucija
AU  - Zhao, Ling
AU  - Margulies, Daniel S.
AU  - Zilles, Karl
AU  - Wang, Xiao-Jing
AU  - Palomero-Gallagher, Nicola
TI  - Gradients of neurotransmitter receptor expression in the macaque cortex
JO  - Nature neuroscience
VL  - 26
SN  - 1097-6256
CY  - New York, NY
PB  - Nature America
M1  - FZJ-2023-02432
SP  - 1281-1294
PY  - 2023
AB  - Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.
LB  - PUB:(DE-HGF)16
C6  - 37336976
UR  - <Go to ISI:>//WOS:001010712900004
DO  - DOI:10.1038/s41593-023-01351-2
UR  - https://juser.fz-juelich.de/record/1008615
ER  -