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@ARTICLE{FroudistWalsh:1008615,
      author       = {Froudist-Walsh, Sean and Xu, Ting and Niu, Meiqi and Rapan,
                      Lucija and Zhao, Ling and Margulies, Daniel S. and Zilles,
                      Karl and Wang, Xiao-Jing and Palomero-Gallagher, Nicola},
      title        = {{G}radients of neurotransmitter receptor expression in the
                      macaque cortex},
      journal      = {Nature neuroscience},
      volume       = {26},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {FZJ-2023-02432},
      pages        = {1281-1294},
      year         = {2023},
      abstract     = {Dynamics and functions of neural circuits depend on
                      interactions mediated by receptors. Therefore, a
                      comprehensive map of receptor organization across cortical
                      regions is needed. In this study, we used in vitro receptor
                      autoradiography to measure the density of 14
                      neurotransmitter receptor types in 109 areas of macaque
                      cortex. We integrated the receptor data with anatomical,
                      genetic and functional connectivity data into a common
                      cortical space. We uncovered a principal gradient of
                      receptor expression per neuron. This aligns with the
                      cortical hierarchy from sensory cortex to higher cognitive
                      areas. A second gradient, driven by serotonin 5-HT1A
                      receptors, peaks in the anterior cingulate, default mode and
                      salience networks. We found a similar pattern of 5-HT1A
                      expression in the human brain. Thus, the macaque may be a
                      promising translational model of serotonergic processing and
                      disorders. The receptor gradients may enable rapid, reliable
                      information processing in sensory cortical areas and slow,
                      flexible integration in higher cognitive areas.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539) / HIBALL - Helmholtz International
                      BigBrain Analytics and Learning Laboratory (HIBALL)
                      (InterLabs-0015) / 3D-MMA - Gradienten der Verteilung
                      multipler Transmitterrezeptoren in der Hirnrinde als
                      Grundlage verteilter kognitiver, sensorischer und
                      motorischer Funktionen. (01GQ1902)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539 /
                      G:(DE-HGF)InterLabs-0015 / G:(BMBF)01GQ1902},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37336976},
      UT           = {WOS:001010712900004},
      doi          = {10.1038/s41593-023-01351-2},
      url          = {https://juser.fz-juelich.de/record/1008615},
}